Results for TP73

General Information

Gene ID 7161
Gene Symbol TP73
Gene Name tumor protein p73
Gene Type protein-coding
Cytoband 1p36.3
Ensembl ID ENSG00000078900
#miR regulators 12
Omim ID 601990
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0000187: activation of MAPK activity
GO:0001822: kidney development
GO:0001836: release of cytochrome c from mitochondria
GO:0006298: mismatch repair
GO:0006351: transcription, DNA-dependent
GO:0006954: inflammatory response
GO:0006974: response to DNA damage stimulus
GO:0006978: DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007050: cell cycle arrest
GO:0008630: intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009791: post-embryonic development
GO:0010165: response to X-ray
GO:0010243: response to organonitrogen compound
GO:0010332: response to gamma radiation
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0021766: hippocampus development
GO:0031571: mitotic G1 DNA damage checkpoint
GO:0033326: cerebrospinal fluid secretion
GO:0034644: cellular response to UV
GO:0042771: intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043065: positive regulation of apoptotic process
GO:0043508: negative regulation of JUN kinase activity
GO:0043524: negative regulation of neuron apoptotic process
GO:0045665: negative regulation of neuron differentiation
GO:0045793: positive regulation of cell size
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048546: digestive tract morphogenesis
GO:0048666: neuron development
GO:0048714: positive regulation of oligodendrocyte differentiation
GO:0051262: protein tetramerization
GO:0000785: chromatin
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005667: transcription factor complex
GO:0005515: protein binding
GO:0002039: p53 binding
GO:0003682: chromatin binding
GO:0003684: damaged DNA binding
GO:0003690: double-stranded DNA binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0046872: metal ion binding
GO:0008134: transcription factor binding
GO:0042802: identical protein binding
GO:0044212: transcription regulatory region DNA binding
GO:0019901: protein kinase binding
GO:0043565: sequence-specific DNA binding
KEGG pathways 4115: p53 signaling pathway
4722: Neurotrophin signaling pathway

PubMed abstracts associated with TP73

PMID Title Tumor Value
12789260 Triggering of p73-dependent apoptosis in osteosarcoma is under the control of E2Fs-pRb2/p130 complexes. no no
15237589 Low expression of p63 and p73 in osteosarcoma. yes no
17568187 Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines. no no
19541929 Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas. no no
19779497 p73 is essential for vitamin D-mediated osteoblastic differentiation. no no
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