General Information
Gene ID | 7186 |
---|---|
Gene Symbol | TRAF2 |
Gene Name | TNF receptor-associated factor 2 |
Gene Type | protein-coding |
Cytoband | 9q34 |
Ensembl ID | ENSG00000127191 |
#miR regulators | 3 |
Omim ID | 601895 |
Gene ontology |
GO:0002726: positive regulation of T cell cytokine production GO:0006915: apoptotic process GO:0007165: signal transduction GO:0006461: protein complex assembly GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0007250: activation of NF-kappaB-inducing kinase activity GO:0042981: regulation of apoptotic process GO:0030163: protein catabolic process GO:0032743: positive regulation of interleukin-2 production GO:0033209: tumor necrosis factor-mediated signaling pathway GO:0043507: positive regulation of JUN kinase activity GO:0043623: cellular protein complex assembly GO:0045087: innate immune response GO:0050870: positive regulation of T cell activation GO:0051023: regulation of immunoglobulin secretion GO:0051091: positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092: positive regulation of NF-kappaB transcription factor activity GO:0051865: protein autoubiquitination GO:0070207: protein homotrimerization GO:0070534: protein K63-linked ubiquitination GO:0090073: positive regulation of protein homodimerization activity GO:0097190: apoptotic signaling pathway GO:2001238: positive regulation of extrinsic apoptotic signaling pathway GO:2001239: regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:0005829: cytosol GO:0005737: cytoplasm GO:0009898: internal side of plasma membrane GO:0035631: CD40 receptor complex GO:0005515: protein binding GO:0004842: ubiquitin-protein ligase activity GO:0004871: signal transducer activity GO:0005164: tumor necrosis factor receptor binding GO:0005174: CD40 receptor binding GO:0008270: zinc ion binding GO:0042802: identical protein binding GO:0019899: enzyme binding GO:0019903: protein phosphatase binding GO:0031625: ubiquitin protein ligase binding GO:0031996: thioesterase binding GO:0046625: sphingolipid binding |
KEGG pathways |
4010: MAPK signaling pathway 4141: Protein processing in endoplasmic reticulum 4210: Apoptosis 4380: Osteoclast differentiation 4622: RIG-I-like receptor signaling pathway 4920: Adipocytokine signaling pathway 5160: Hepatitis C 5200: Pathways in cancer 5222: Small cell lung cancer |
PMID | Title | Tumor | Value |
---|---|---|---|
22068640 | Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines. | no | no |
title | all | all |