Results for TRAF6

General Information

Gene ID 7189
Gene Symbol TRAF6
Gene Name TNF receptor-associated factor 6, E3 ubiquitin protein ligase
Gene Type protein-coding
Cytoband 11p12
Ensembl ID ENSG00000175104
#miR regulators 20
Omim ID 602355
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0000187: activation of MAPK activity
GO:0000209: protein polyubiquitination
GO:0001503: ossification
GO:0001843: neural tube closure
GO:0002224: toll-like receptor signaling pathway
GO:0002726: positive regulation of T cell cytokine production
GO:0002755: MyD88-dependent toll-like receptor signaling pathway
GO:0002756: MyD88-independent toll-like receptor signaling pathway
GO:0006461: protein complex assembly
GO:0007249: I-kappaB kinase/NF-kappaB cascade
GO:0007250: activation of NF-kappaB-inducing kinase activity
GO:0007254: JNK cascade
GO:0043066: negative regulation of apoptotic process
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0019886: antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0050852: T cell receptor signaling pathway
GO:0030316: osteoclast differentiation
GO:0031293: membrane protein intracellular domain proteolysis
GO:0031398: positive regulation of protein ubiquitination
GO:0031666: positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0032147: activation of protein kinase activity
GO:0032743: positive regulation of interleukin-2 production
GO:0034134: toll-like receptor 2 signaling pathway
GO:0034138: toll-like receptor 3 signaling pathway
GO:0034142: toll-like receptor 4 signaling pathway
GO:0034146: toll-like receptor 5 signaling pathway
GO:0034162: toll-like receptor 9 signaling pathway
GO:0034166: toll-like receptor 10 signaling pathway
GO:0035666: TRIF-dependent toll-like receptor signaling pathway
GO:0035872: nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0038123: toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124: toll-like receptor TLR6:TLR2 signaling pathway
GO:0042088: T-helper 1 type immune response
GO:0042102: positive regulation of T cell proliferation
GO:0042475: odontogenesis of dentin-containing tooth
GO:0043011: myeloid dendritic cell differentiation
GO:0043065: positive regulation of apoptotic process
GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043507: positive regulation of JUN kinase activity
GO:0045084: positive regulation of interleukin-12 biosynthetic process
GO:0045087: innate immune response
GO:0045410: positive regulation of interleukin-6 biosynthetic process
GO:0045453: bone resorption
GO:0045672: positive regulation of osteoclast differentiation
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0048468: cell development
GO:0048661: positive regulation of smooth muscle cell proliferation
GO:0050870: positive regulation of T cell activation
GO:0051023: regulation of immunoglobulin secretion
GO:0051091: positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092: positive regulation of NF-kappaB transcription factor activity
GO:0051403: stress-activated MAPK cascade
GO:0051865: protein autoubiquitination
GO:0070423: nucleotide-binding oligomerization domain containing signaling pathway
GO:0070498: interleukin-1-mediated signaling pathway
GO:0070534: protein K63-linked ubiquitination
GO:0070555: response to interleukin-1
GO:0097190: apoptotic signaling pathway
GO:2000679: positive regulation of transcription regulatory region DNA binding
GO:0005886: plasma membrane
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005811: lipid particle
GO:0005938: cell cortex
GO:0009898: internal side of plasma membrane
GO:0010008: endosome membrane
GO:0031965: nuclear membrane
GO:0035631: CD40 receptor complex
GO:0048471: perinuclear region of cytoplasm
GO:0005515: protein binding
GO:0004842: ubiquitin-protein ligase activity
GO:0004871: signal transducer activity
GO:0008270: zinc ion binding
GO:0019901: protein kinase binding
GO:0031435: mitogen-activated protein kinase kinase kinase binding
GO:0031625: ubiquitin protein ligase binding
GO:0031996: thioesterase binding
GO:0042826: histone deacetylase binding
GO:0043422: protein kinase B binding
GO:0047485: protein N-terminus binding
KEGG pathways 4010: MAPK signaling pathway
4120: Ubiquitin mediated proteolysis
4144: Endocytosis
4380: Osteoclast differentiation
4620: Toll-like receptor signaling pathway
4621: NOD-like receptor signaling pathway
4622: RIG-I-like receptor signaling pathway
4722: Neurotrophin signaling pathway
5140: Leishmaniasis
5142: Chagas disease (American trypanosomiasis)
5145: Toxoplasmosis
5160: Hepatitis C
5200: Pathways in cancer
5222: Small cell lung cancer

PubMed abstracts associated with TRAF6

PMID Title Tumor Value
22886393 TRAF6 regulates proliferation, apoptosis, and invasion of osteosarcoma cell. yes no
title all all