General Information
Gene ID | 7189 |
---|---|
Gene Symbol | TRAF6 |
Gene Name | TNF receptor-associated factor 6, E3 ubiquitin protein ligase |
Gene Type | protein-coding |
Cytoband | 11p12 |
Ensembl ID | ENSG00000175104 |
#miR regulators | 20 |
Omim ID | 602355 |
Gene ontology |
GO:0000122: negative regulation of transcription from RNA polymerase II promoter GO:0000187: activation of MAPK activity GO:0000209: protein polyubiquitination GO:0001503: ossification GO:0001843: neural tube closure GO:0002224: toll-like receptor signaling pathway GO:0002726: positive regulation of T cell cytokine production GO:0002755: MyD88-dependent toll-like receptor signaling pathway GO:0002756: MyD88-independent toll-like receptor signaling pathway GO:0006461: protein complex assembly GO:0007249: I-kappaB kinase/NF-kappaB cascade GO:0007250: activation of NF-kappaB-inducing kinase activity GO:0007254: JNK cascade GO:0043066: negative regulation of apoptotic process GO:0045892: negative regulation of transcription, DNA-dependent GO:0019886: antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0050852: T cell receptor signaling pathway GO:0030316: osteoclast differentiation GO:0031293: membrane protein intracellular domain proteolysis GO:0031398: positive regulation of protein ubiquitination GO:0031666: positive regulation of lipopolysaccharide-mediated signaling pathway GO:0032147: activation of protein kinase activity GO:0032743: positive regulation of interleukin-2 production GO:0034134: toll-like receptor 2 signaling pathway GO:0034138: toll-like receptor 3 signaling pathway GO:0034142: toll-like receptor 4 signaling pathway GO:0034146: toll-like receptor 5 signaling pathway GO:0034162: toll-like receptor 9 signaling pathway GO:0034166: toll-like receptor 10 signaling pathway GO:0035666: TRIF-dependent toll-like receptor signaling pathway GO:0035872: nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0038095: Fc-epsilon receptor signaling pathway GO:0038123: toll-like receptor TLR1:TLR2 signaling pathway GO:0038124: toll-like receptor TLR6:TLR2 signaling pathway GO:0042088: T-helper 1 type immune response GO:0042102: positive regulation of T cell proliferation GO:0042475: odontogenesis of dentin-containing tooth GO:0043011: myeloid dendritic cell differentiation GO:0043065: positive regulation of apoptotic process GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043507: positive regulation of JUN kinase activity GO:0045084: positive regulation of interleukin-12 biosynthetic process GO:0045087: innate immune response GO:0045410: positive regulation of interleukin-6 biosynthetic process GO:0045453: bone resorption GO:0045672: positive regulation of osteoclast differentiation GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0048011: neurotrophin TRK receptor signaling pathway GO:0048468: cell development GO:0048661: positive regulation of smooth muscle cell proliferation GO:0050870: positive regulation of T cell activation GO:0051023: regulation of immunoglobulin secretion GO:0051091: positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092: positive regulation of NF-kappaB transcription factor activity GO:0051403: stress-activated MAPK cascade GO:0051865: protein autoubiquitination GO:0070423: nucleotide-binding oligomerization domain containing signaling pathway GO:0070498: interleukin-1-mediated signaling pathway GO:0070534: protein K63-linked ubiquitination GO:0070555: response to interleukin-1 GO:0097190: apoptotic signaling pathway GO:2000679: positive regulation of transcription regulatory region DNA binding GO:0005886: plasma membrane GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0005811: lipid particle GO:0005938: cell cortex GO:0009898: internal side of plasma membrane GO:0010008: endosome membrane GO:0031965: nuclear membrane GO:0035631: CD40 receptor complex GO:0048471: perinuclear region of cytoplasm GO:0005515: protein binding GO:0004842: ubiquitin-protein ligase activity GO:0004871: signal transducer activity GO:0008270: zinc ion binding GO:0019901: protein kinase binding GO:0031435: mitogen-activated protein kinase kinase kinase binding GO:0031625: ubiquitin protein ligase binding GO:0031996: thioesterase binding GO:0042826: histone deacetylase binding GO:0043422: protein kinase B binding GO:0047485: protein N-terminus binding |
KEGG pathways |
4010: MAPK signaling pathway 4120: Ubiquitin mediated proteolysis 4144: Endocytosis 4380: Osteoclast differentiation 4620: Toll-like receptor signaling pathway 4621: NOD-like receptor signaling pathway 4622: RIG-I-like receptor signaling pathway 4722: Neurotrophin signaling pathway 5140: Leishmaniasis 5142: Chagas disease (American trypanosomiasis) 5145: Toxoplasmosis 5160: Hepatitis C 5200: Pathways in cancer 5222: Small cell lung cancer |
PMID | Title | Tumor | Value |
---|---|---|---|
22886393 | TRAF6 regulates proliferation, apoptosis, and invasion of osteosarcoma cell. | yes | no |
title | all | all |