Results for TWIST1

General Information

Gene ID 7291
Gene Symbol TWIST1
Gene Name twist basic helix-loop-helix transcription factor 1
Gene Type protein-coding
Cytoband 7p21.2
Ensembl ID ENSG00000122691
#miR regulators 4
Omim ID 101400 123100 180750 601622
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0001503: ossification
GO:0001649: osteoblast differentiation
GO:0001701: in utero embryonic development
GO:0001764: neuron migration
GO:0001843: neural tube closure
GO:0003180: aortic valve morphogenesis
GO:0003183: mitral valve morphogenesis
GO:0003203: endocardial cushion morphogenesis
GO:0003253: cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:0006366: transcription from RNA polymerase II promoter
GO:0006915: apoptotic process
GO:0007517: muscle organ development
GO:0010628: positive regulation of gene expression
GO:0010718: positive regulation of epithelial to mesenchymal transition
GO:0014067: negative regulation of phosphatidylinositol 3-kinase cascade
GO:0030500: regulation of bone mineralization
GO:0032000: positive regulation of fatty acid beta-oxidation
GO:0032720: negative regulation of tumor necrosis factor production
GO:0032760: positive regulation of tumor necrosis factor production
GO:0033128: negative regulation of histone phosphorylation
GO:0035067: negative regulation of histone acetylation
GO:0035115: embryonic forelimb morphogenesis
GO:0035116: embryonic hindlimb morphogenesis
GO:0035359: negative regulation of peroxisome proliferator activated receptor signaling pathway
GO:0042473: outer ear morphogenesis
GO:0042733: embryonic digit morphogenesis
GO:0043433: negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043518: negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045668: negative regulation of osteoblast differentiation
GO:0045766: positive regulation of angiogenesis
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048642: negative regulation of skeletal muscle tissue development
GO:0048701: embryonic cranial skeleton morphogenesis
GO:0060363: cranial suture morphogenesis
GO:0060900: embryonic camera-type eye formation
GO:0061029: eyelid development in camera-type eye
GO:0071456: cellular response to hypoxia
GO:0071639: positive regulation of monocyte chemotactic protein-1 production
GO:2000147: positive regulation of cell motility
GO:2000276: negative regulation of oxidative phosphorylation uncoupler activity
GO:2000679: positive regulation of transcription regulatory region DNA binding
GO:2000773: negative regulation of cellular senescence
GO:2000778: positive regulation of interleukin-6 secretion
GO:2000780: negative regulation of double-strand break repair
GO:2000793: cell proliferation involved in heart valve development
GO:2000802: positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation
GO:0005634: nucleus
GO:0005515: protein binding
GO:0000981: sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0008134: transcription factor binding
GO:0019904: protein domain specific binding
GO:0042803: protein homodimerization activity
GO:0043425: bHLH transcription factor binding
GO:0046982: protein heterodimerization activity
GO:0070888: E-box binding
KEGG pathways ---

PubMed abstracts associated with TWIST1

PMID Title Tumor Value
15900593 Frequent genomic abnormalities at TWIST in human pediatric osteosarcomas. yes yes
17318900 Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells. no no
17786187 Involvement of MET/TWIST/APC combination or the potential role of ossification factors in pediatric high-grade osteosarcoma oncogenesis. yes yes
22847601 Prognostic value of Twist and E-cadherin in patients with osteosarcoma. yes yes
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