General Information
Gene ID | 7291 |
---|---|
Gene Symbol | TWIST1 |
Gene Name | twist basic helix-loop-helix transcription factor 1 |
Gene Type | protein-coding |
Cytoband | 7p21.2 |
Ensembl ID | ENSG00000122691 |
#miR regulators | 4 |
Omim ID | 101400 123100 180750 601622 |
Gene ontology |
GO:0000122: negative regulation of transcription from RNA polymerase II promoter GO:0001503: ossification GO:0001649: osteoblast differentiation GO:0001701: in utero embryonic development GO:0001764: neuron migration GO:0001843: neural tube closure GO:0003180: aortic valve morphogenesis GO:0003183: mitral valve morphogenesis GO:0003203: endocardial cushion morphogenesis GO:0003253: cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0006366: transcription from RNA polymerase II promoter GO:0006915: apoptotic process GO:0007517: muscle organ development GO:0010628: positive regulation of gene expression GO:0010718: positive regulation of epithelial to mesenchymal transition GO:0014067: negative regulation of phosphatidylinositol 3-kinase cascade GO:0030500: regulation of bone mineralization GO:0032000: positive regulation of fatty acid beta-oxidation GO:0032720: negative regulation of tumor necrosis factor production GO:0032760: positive regulation of tumor necrosis factor production GO:0033128: negative regulation of histone phosphorylation GO:0035067: negative regulation of histone acetylation GO:0035115: embryonic forelimb morphogenesis GO:0035116: embryonic hindlimb morphogenesis GO:0035359: negative regulation of peroxisome proliferator activated receptor signaling pathway GO:0042473: outer ear morphogenesis GO:0042733: embryonic digit morphogenesis GO:0043433: negative regulation of sequence-specific DNA binding transcription factor activity GO:0043518: negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0045668: negative regulation of osteoblast differentiation GO:0045766: positive regulation of angiogenesis GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0048642: negative regulation of skeletal muscle tissue development GO:0048701: embryonic cranial skeleton morphogenesis GO:0060363: cranial suture morphogenesis GO:0060900: embryonic camera-type eye formation GO:0061029: eyelid development in camera-type eye GO:0071456: cellular response to hypoxia GO:0071639: positive regulation of monocyte chemotactic protein-1 production GO:2000147: positive regulation of cell motility GO:2000276: negative regulation of oxidative phosphorylation uncoupler activity GO:2000679: positive regulation of transcription regulatory region DNA binding GO:2000773: negative regulation of cellular senescence GO:2000778: positive regulation of interleukin-6 secretion GO:2000780: negative regulation of double-strand break repair GO:2000793: cell proliferation involved in heart valve development GO:2000802: positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:0005634: nucleus GO:0005515: protein binding GO:0000981: sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0008134: transcription factor binding GO:0019904: protein domain specific binding GO:0042803: protein homodimerization activity GO:0043425: bHLH transcription factor binding GO:0046982: protein heterodimerization activity GO:0070888: E-box binding |
KEGG pathways | --- |
PMID | Title | Tumor | Value |
---|---|---|---|
15900593 | Frequent genomic abnormalities at TWIST in human pediatric osteosarcomas. | yes | yes |
17318900 | Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells. | no | no |
17786187 | Involvement of MET/TWIST/APC combination or the potential role of ossification factors in pediatric high-grade osteosarcoma oncogenesis. | yes | yes |
22847601 | Prognostic value of Twist and E-cadherin in patients with osteosarcoma. | yes | yes |
title | all | all |