General Information
Gene ID | 7298 |
---|---|
Gene Symbol | TYMS |
Gene Name | thymidylate synthetase |
Gene Type | protein-coding |
Cytoband | 18p11.32 |
Ensembl ID | ENSG00000176890 |
#miR regulators | 1 |
Omim ID | 188350 |
Gene ontology |
GO:0006260: DNA replication GO:0000082: G1/S transition of mitotic cell cycle GO:0000083: regulation of transcription involved in G1/S phase of mitotic cell cycle GO:0000278: mitotic cell cycle GO:0005976: polysaccharide metabolic process GO:0006139: nucleobase-containing compound metabolic process GO:0006206: pyrimidine nucleobase metabolic process GO:0006231: dTMP biosynthetic process GO:0006235: dTTP biosynthetic process GO:0006281: DNA repair GO:0007568: aging GO:0007623: circadian rhythm GO:0046683: response to organophosphorus GO:0009157: deoxyribonucleoside monophosphate biosynthetic process GO:0042493: response to drug GO:0009636: response to toxic substance GO:0019088: immortalization of host cell by virus GO:0019860: uracil metabolic process GO:0048015: phosphatidylinositol-mediated signaling GO:0031100: organ regeneration GO:0032570: response to progesterone stimulus GO:0033189: response to vitamin A GO:0034097: response to cytokine stimulus GO:0044281: small molecule metabolic process GO:0045471: response to ethanol GO:0046078: dUMP metabolic process GO:0046134: pyrimidine nucleoside biosynthetic process GO:0046653: tetrahydrofolate metabolic process GO:0048589: developmental growth GO:0051216: cartilage development GO:0051384: response to glucocorticoid stimulus GO:0051593: response to folic acid GO:0055086: nucleobase-containing small molecule metabolic process GO:0060574: intestinal epithelial cell maturation GO:0005739: mitochondrion GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0005654: nucleoplasm GO:0005730: nucleolus GO:0005743: mitochondrial inner membrane GO:0005759: mitochondrial matrix GO:0000166: nucleotide binding GO:0003729: mRNA binding GO:0004799: thymidylate synthase activity GO:0005542: folic acid binding GO:0008144: drug binding GO:0042803: protein homodimerization activity GO:0048037: cofactor binding |
KEGG pathways |
240: Pyrimidine metabolism 670: One carbon pool by folate 1100: Metabolic pathways |
PMID | Title | Tumor | Value |
---|---|---|---|
9187120 | Overexpression of p21waf1 leads to increased inhibition of E2F-1 phosphorylation and sensitivity to anticancer drugs in retinoblastoma-negative human sarcoma cells. | no | no |
12813132 | mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma. | yes | yes |
20433742 | Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells. | no | no |
title | all | all |