Results for TYMS

General Information

Gene ID 7298
Gene Symbol TYMS
Gene Name thymidylate synthetase
Gene Type protein-coding
Cytoband 18p11.32
Ensembl ID ENSG00000176890
#miR regulators 1
Omim ID 188350
Gene ontology GO:0006260: DNA replication
GO:0000082: G1/S transition of mitotic cell cycle
GO:0000083: regulation of transcription involved in G1/S phase of mitotic cell cycle
GO:0000278: mitotic cell cycle
GO:0005976: polysaccharide metabolic process
GO:0006139: nucleobase-containing compound metabolic process
GO:0006206: pyrimidine nucleobase metabolic process
GO:0006231: dTMP biosynthetic process
GO:0006235: dTTP biosynthetic process
GO:0006281: DNA repair
GO:0007568: aging
GO:0007623: circadian rhythm
GO:0046683: response to organophosphorus
GO:0009157: deoxyribonucleoside monophosphate biosynthetic process
GO:0042493: response to drug
GO:0009636: response to toxic substance
GO:0019088: immortalization of host cell by virus
GO:0019860: uracil metabolic process
GO:0048015: phosphatidylinositol-mediated signaling
GO:0031100: organ regeneration
GO:0032570: response to progesterone stimulus
GO:0033189: response to vitamin A
GO:0034097: response to cytokine stimulus
GO:0044281: small molecule metabolic process
GO:0045471: response to ethanol
GO:0046078: dUMP metabolic process
GO:0046134: pyrimidine nucleoside biosynthetic process
GO:0046653: tetrahydrofolate metabolic process
GO:0048589: developmental growth
GO:0051216: cartilage development
GO:0051384: response to glucocorticoid stimulus
GO:0051593: response to folic acid
GO:0055086: nucleobase-containing small molecule metabolic process
GO:0060574: intestinal epithelial cell maturation
GO:0005739: mitochondrion
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005730: nucleolus
GO:0005743: mitochondrial inner membrane
GO:0005759: mitochondrial matrix
GO:0000166: nucleotide binding
GO:0003729: mRNA binding
GO:0004799: thymidylate synthase activity
GO:0005542: folic acid binding
GO:0008144: drug binding
GO:0042803: protein homodimerization activity
GO:0048037: cofactor binding
KEGG pathways 240: Pyrimidine metabolism
670: One carbon pool by folate
1100: Metabolic pathways

PubMed abstracts associated with TYMS

PMID Title Tumor Value
9187120 Overexpression of p21waf1 leads to increased inhibition of E2F-1 phosphorylation and sensitivity to anticancer drugs in retinoblastoma-negative human sarcoma cells. no no
12813132 mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma. yes yes
20433742 Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells. no no
title all all