Results for VDR

General Information

Gene ID 7421
Gene Symbol VDR
Gene Name vitamin D (1,25- dihydroxyvitamin D3) receptor
Gene Type protein-coding
Cytoband 12q13.11
Ensembl ID ENSG00000111424
#miR regulators 6
Omim ID 166710 277440 601769
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0000902: cell morphogenesis
GO:0007165: signal transduction
GO:0006367: transcription initiation from RNA polymerase II promoter
GO:0008285: negative regulation of cell proliferation
GO:0010467: gene expression
GO:0010628: positive regulation of gene expression
GO:0010839: negative regulation of keratinocyte proliferation
GO:0010980: positive regulation of vitamin D 24-hydroxylase activity
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0038183: bile acid signaling pathway
GO:0045618: positive regulation of keratinocyte differentiation
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0046697: decidualization
GO:0060558: regulation of calcidiol 1-monooxygenase activity
GO:0070561: vitamin D receptor signaling pathway
GO:0005634: nucleus
GO:0005654: nucleoplasm
GO:0005515: protein binding
GO:0003677: DNA binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0003707: steroid hormone receptor activity
GO:0008270: zinc ion binding
GO:0008434: calcitriol receptor activity
GO:0038186: lithocholic acid receptor activity
GO:0043565: sequence-specific DNA binding
GO:0046965: retinoid X receptor binding
GO:0070644: vitamin D response element binding
GO:1902098: calcitriol binding
GO:1902121: lithocholic acid binding
KEGG pathways ---

PubMed abstracts associated with VDR

PMID Title Tumor Value
1657330 Hormonal regulation of vitamin D receptor levels and osteocalcin synthesis in human osteosarcoma cells. no no
1846564 Homologous and heterologous regulation of 1,25-dihydroxyvitamin D-3 receptor mRNA levels in human osteosarcoma cells. no no
7802648 Steroid hormone modulation of vitamin D receptor levels in human MG-63 osteosarcoma cells. no no
7817811 Effects of transforming growth factor beta 1 on the regulation of osteocalcin synthesis in human MG-63 osteosarcoma cells. no no
8281940 Insulin-like growth factor-1 modulates steroid hormone effects on osteocalcin synthesis in human MG-63 osteosarcoma cells. no no
10773107 Steroid receptor co-activator-1 mediates 1,25-dihydroxyvitamin D(3)-stimulated alkaline phosphatase in human osteosarcoma cells. no no
14528100 Analysis of polymorphisms of the vitamin D receptor, estrogen receptor, and collagen Ialpha1 genes and their relationship with height in children with bone cancer. yes no
17412493 1alpha,25-Dihydroxyvitamin D(3) antiproliferative actions involve vitamin D receptor-mediated activation of MAPK pathways and AP-1/p21(waf1) upregulation in human osteosarcoma. no no
19779497 p73 is essential for vitamin D-mediated osteoblastic differentiation. no no
21963453 Snail-1 regulates VDR signaling and inhibits 1,25(OH)-D₃ action in osteosarcoma. no no
22542077 Clinicopathologic correlation of vitamin D receptor expression with retinoid X receptor and MIB-1 expression in primary and metastatic osteosarcoma. yes yes
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