Results for VEGFA

General Information

Gene ID 7422
Gene Symbol VEGFA
Gene Name vascular endothelial growth factor A
Gene Type protein-coding
Cytoband 6p12
Ensembl ID ENSG00000112715
#miR regulators 14
Omim ID 192240 603933
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0001525: angiogenesis
GO:0001541: ovarian follicle development
GO:0001569: patterning of blood vessels
GO:0001570: vasculogenesis
GO:0001666: response to hypoxia
GO:0001701: in utero embryonic development
GO:0001822: kidney development
GO:0001934: positive regulation of protein phosphorylation
GO:0001938: positive regulation of endothelial cell proliferation
GO:0002042: cell migration involved in sprouting angiogenesis
GO:0002052: positive regulation of neuroblast proliferation
GO:0002053: positive regulation of mesenchymal cell proliferation
GO:0002092: positive regulation of receptor internalization
GO:0002575: basophil chemotaxis
GO:0002576: platelet degranulation
GO:0002687: positive regulation of leukocyte migration
GO:0003007: heart morphogenesis
GO:0003151: outflow tract morphogenesis
GO:0003169: coronary vein morphogenesis
GO:0007596: blood coagulation
GO:0006357: regulation of transcription from RNA polymerase II promoter
GO:0040007: growth
GO:0007399: nervous system development
GO:0007498: mesoderm development
GO:0007595: lactation
GO:0043066: negative regulation of apoptotic process
GO:0008284: positive regulation of cell proliferation
GO:0008360: regulation of cell shape
GO:0010595: positive regulation of endothelial cell migration
GO:0010628: positive regulation of gene expression
GO:0010740: positive regulation of intracellular protein kinase cascade
GO:0030168: platelet activation
GO:0030224: monocyte differentiation
GO:0030225: macrophage differentiation
GO:0030324: lung development
GO:0030335: positive regulation of cell migration
GO:0030855: epithelial cell differentiation
GO:0030949: positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031077: post-embryonic camera-type eye development
GO:0031334: positive regulation of protein complex assembly
GO:0031954: positive regulation of protein autophosphorylation
GO:0032147: activation of protein kinase activity
GO:0032793: positive regulation of CREB transcription factor activity
GO:0033138: positive regulation of peptidyl-serine phosphorylation
GO:0035148: tube formation
GO:0035767: endothelial cell chemotaxis
GO:0035924: cellular response to vascular endothelial growth factor stimulus
GO:0036303: lymph vessel morphogenesis
GO:0038033: positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0038091: positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0042462: eye photoreceptor cell development
GO:0043117: positive regulation of vascular permeability
GO:0043129: surfactant homeostasis
GO:0043154: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043406: positive regulation of MAP kinase activity
GO:0043536: positive regulation of blood vessel endothelial cell migration
GO:0045766: positive regulation of angiogenesis
GO:0045785: positive regulation of cell adhesion
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048010: vascular endothelial growth factor receptor signaling pathway
GO:0048469: cell maturation
GO:0048593: camera-type eye morphogenesis
GO:0048739: cardiac muscle fiber development
GO:0048754: branching morphogenesis of an epithelial tube
GO:0048842: positive regulation of axon extension involved in axon guidance
GO:0048844: artery morphogenesis
GO:0050679: positive regulation of epithelial cell proliferation
GO:0050731: positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918: positive chemotaxis
GO:0050927: positive regulation of positive chemotaxis
GO:0050930: induction of positive chemotaxis
GO:0051272: positive regulation of cellular component movement
GO:0051781: positive regulation of cell division
GO:0051894: positive regulation of focal adhesion assembly
GO:0060319: primitive erythrocyte differentiation
GO:0060749: mammary gland alveolus development
GO:0060754: positive regulation of mast cell chemotaxis
GO:0060948: cardiac vascular smooth muscle cell development
GO:0060982: coronary artery morphogenesis
GO:0061418: regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061419: positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456: cellular response to hypoxia
GO:0071542: dopaminergic neuron differentiation
GO:0071679: commissural neuron axon guidance
GO:0090037: positive regulation of protein kinase C signaling cascade
GO:0090050: positive regulation of cell migration involved in sprouting angiogenesis
GO:0090190: positive regulation of branching involved in ureteric bud morphogenesis
GO:0090259: regulation of retinal ganglion cell axon guidance
GO:1900086: positive regulation of peptidyl-tyrosine autophosphorylation
GO:1900745: positive regulation of p38MAPK cascade
GO:1901727: positive regulation of histone deacetylase activity
GO:1902336: positive regulation of retinal ganglion cell axon guidance
GO:0016020: membrane
GO:0005576: extracellular region
GO:0005578: proteinaceous extracellular matrix
GO:0005615: extracellular space
GO:0005737: cytoplasm
GO:0030141: secretory granule
GO:0009986: cell surface
GO:0031093: platelet alpha granule lumen
GO:0005515: protein binding
GO:0001968: fibronectin binding
GO:0005125: cytokine activity
GO:0005161: platelet-derived growth factor receptor binding
GO:0005172: vascular endothelial growth factor receptor binding
GO:0008083: growth factor activity
GO:0008201: heparin binding
GO:0042802: identical protein binding
GO:0048018: receptor agonist activity
GO:0050840: extracellular matrix binding
GO:0042056: chemoattractant activity
GO:0042803: protein homodimerization activity
GO:0043183: vascular endothelial growth factor receptor 1 binding
GO:0043184: vascular endothelial growth factor receptor 2 binding
GO:0046982: protein heterodimerization activity
KEGG pathways 4060: Cytokine-cytokine receptor interaction
4150: mTOR signaling pathway
4370: VEGF signaling pathway
4510: Focal adhesion
5200: Pathways in cancer
5211: Renal cell carcinoma
5212: Pancreatic cancer
5219: Bladder cancer
5323: Rheumatoid arthritis

PubMed abstracts associated with VEGFA

PMID Title Tumor Value
7528503 Quantitative RT-PCR assay detecting the transcriptional induction of vascular endothelial growth factor under hypoxia. no no
10533453 Cell-retained isoforms of vascular endothelial growth factor (VEGF) are correlated with poor prognosis in osteosarcoma. yes yes
10690541 Vascular endothelial growth factor expression in untreated osteosarcoma is predictive of pulmonary metastasis and poor prognosis. yes yes
10891538 Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma. yes yes
11953816 Increased pre-therapeutic serum vascular endothelial growth factor in patients with early clinical relapse of osteosarcoma. yes yes
12404059 Expression of osteopontin and vascular endothelial growth factor in benign and malignant bone tumors. yes no
14598359 Cytokine and cytokine receptor serum levels in adult bone sarcoma patients: correlations with local tumor extent and prognosis. yes yes
15346048 VEGF expression in osteosarcoma correlates with vascular permeability by dynamic MRI. yes yes
15985268 Pigment epithelium-derived factor (PEDF)-induced apoptosis and inhibition of vascular endothelial growth factor (VEGF) expression in MG63 human osteosarcoma cells. no no
16119739 Expression and significance of TGF-beta isoform and VEGF in osteosarcoma. yes yes
16528367 CXCR4 and VEGF expression in the primary site and the metastatic site of human osteosarcoma: analysis within a group of patients, all of whom developed lung metastasis. yes yes
16786118 Does the degree of intratumoural microvessel density and VEGF expression have prognostic significance in osteosarcoma? yes no
16826116 Vascular endothelial growth factor expression in osteosarcoma. yes yes
17310851 Inhibition of hypoxia-induced angiogenesis by trichostatin A via suppression of HIF-1a activity in human osteosarcoma. no no
17549480 Effect of cortisol on cell proliferation and the expression of lipoprotein lipase and vascular endothelial growth factor in a human osteosarcoma cell line. no no
17690908 Possible prognostic role of IL-17R in osteosarcoma. no yes
17892509 Vector-based Ape1 small interfering RNA enhances the sensitivity of human osteosarcoma cells to endostatin in vivo. no no
17980359 Icariside II from Epimedium koreanum inhibits hypoxia-inducible factor-1alpha in human osteosarcoma cells. no no
18332870 Cisplatin treatment increases survival and expansion of a highly tumorigenic side-population fraction by upregulating VEGF/Flt1 autocrine signaling. no no
18339860 Deletion of Yin Yang 1 protein in osteosarcoma cells on cell invasion and CXCR4/angiogenesis and metastasis. no no
18438338 VEGF-siRNA silencing induces apoptosis, inhibits proliferation and suppresses vasculogenic mimicry in osteosarcoma in vitro. yes no
18528739 Hypoxia markers in human osteosarcoma: an exploratory study. yes no
18563508 Expression of macrophage migration inhibitory factor relates to survival in high-grade osteosarcoma. yes no
18771083 VEGF165 is necessary to the metastatic potential of Fas(-) osteosarcoma cells but will not rescue the Fas(+) cells. no no
18854653 Prognostic significance of alpha V integrin and VEGF in osteosarcoma after chemotherapy. yes yes
19483233 The level of vascular endothelial growth factor as a predictor of a poor prognosis in osteosarcoma. yes no
19621435 VEGF expression as a prognostic marker in osteosarcoma. yes yes
19789339 The insulin-like growth factor-1 receptor-targeting antibody, CP-751,871, suppresses tumor-derived VEGF and synergizes with rapamycin in models of childhood sarcoma. no no
19836228 VEGF and EMMPRIN expression correlates with survival of patients with osteosarcoma. yes yes
20003259 Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways. yes no
20158913 Neoadjuvant multidrug chemotherapy including high-dose methotrexate modifies VEGF expression in osteosarcoma: an immunohistochemical analysis. yes yes
20349215 Relationships between levels of CXCR4 and VEGF and blood-borne metastasis and survival in patients with osteosarcoma. yes yes
20701666 Proliferative, apoptotic and angiogenic potentials in jaws and long bones osteosarcomas: a comparative immunohistochemical study. yes no
21240382 Expression of molecular markers in the tumor and survival prognosis in osteosarcoma. yes yes
21375766 RNAi-mediated knockdown of cyclooxygenase2 inhibits the growth, invasion and migration of SaOS2 human osteosarcoma cells: a case control study. no no
21416580 A prognostic evaluation of vascular endothelial growth factor in children and young adults with osteosarcoma. yes yes
21443800 The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. no no
21481226 Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines. no no
21495021 Genetic amplification of the vascular endothelial growth factor (VEGF) pathway genes, including VEGFA, in human osteosarcoma. yes yes
21986150 Difference in pre- and postchemotherapy vascular endothelial growth factor levels as a prognostic indicator in osteosarcoma. yes yes
22274866 The prognostic value of elevated vascular endothelial growth factor in patients with osteosarcoma: a meta-analysis and systemic review. yes yes
22472569 MicroRNA-145 targets vascular endothelial growth factor and inhibits invasion and metastasis of osteosarcoma cells. yes no
22641358 Combined administration of EGCG and IL-1 receptor antagonist efficiently downregulates IL-1-induced tumorigenic factors in U-2 OS human osteosarcoma cells. no no
22855059 Expression of Vascular Endothelial Growth Factor correlates with the advance of clinical osteosarcoma. yes yes
23015149 Role of vascular endothelial growth factor as a tumour marker in osteosarcoma: a prospective study. yes yes
23219526 Interleukin-6 induces vascular endothelial growth factor expression and promotes angiogenesis through apoptosis signal-regulating kinase 1 in human osteosarcoma. no no
23167426 Clinical predictive value of serum angiogenic factor in patients with osteosarcoma. yes yes
23192273 IL-17A/IL-17RA interaction promoted metastasis of osteosarcoma cells. yes no
23403511 Rapamycin increases pCREB, Bcl-2, and VEGF-A through ERK under normoxia. no no
23430952 Diallyl trisulfide inhibits proliferation, invasion and angiogenesis of osteosarcoma cells by switching on suppressor microRNAs and inactivating of Notch-1 signaling. no no
23589053 A systematic review of vascular endothelial growth factor expression as a biomarker of prognosis in patients with osteosarcoma. yes yes
23740448 Relaxin promotes in vitro tumour growth, invasion and angiogenesis of human Saos-2 osteosarcoma cells by AKT/VEGF pathway. no no
23879172 FIM-A, a phosphorus-containing sirolimus, inhibits the angiogenesis and proliferation of osteosarcomas. no no
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