General Information
Gene ID | 7422 |
---|---|
Gene Symbol | VEGFA |
Gene Name | vascular endothelial growth factor A |
Gene Type | protein-coding |
Cytoband | 6p12 |
Ensembl ID | ENSG00000112715 |
#miR regulators | 14 |
Omim ID | 192240 603933 |
Gene ontology |
GO:0000122: negative regulation of transcription from RNA polymerase II promoter GO:0001525: angiogenesis GO:0001541: ovarian follicle development GO:0001569: patterning of blood vessels GO:0001570: vasculogenesis GO:0001666: response to hypoxia GO:0001701: in utero embryonic development GO:0001822: kidney development GO:0001934: positive regulation of protein phosphorylation GO:0001938: positive regulation of endothelial cell proliferation GO:0002042: cell migration involved in sprouting angiogenesis GO:0002052: positive regulation of neuroblast proliferation GO:0002053: positive regulation of mesenchymal cell proliferation GO:0002092: positive regulation of receptor internalization GO:0002575: basophil chemotaxis GO:0002576: platelet degranulation GO:0002687: positive regulation of leukocyte migration GO:0003007: heart morphogenesis GO:0003151: outflow tract morphogenesis GO:0003169: coronary vein morphogenesis GO:0007596: blood coagulation GO:0006357: regulation of transcription from RNA polymerase II promoter GO:0040007: growth GO:0007399: nervous system development GO:0007498: mesoderm development GO:0007595: lactation GO:0043066: negative regulation of apoptotic process GO:0008284: positive regulation of cell proliferation GO:0008360: regulation of cell shape GO:0010595: positive regulation of endothelial cell migration GO:0010628: positive regulation of gene expression GO:0010740: positive regulation of intracellular protein kinase cascade GO:0030168: platelet activation GO:0030224: monocyte differentiation GO:0030225: macrophage differentiation GO:0030324: lung development GO:0030335: positive regulation of cell migration GO:0030855: epithelial cell differentiation GO:0030949: positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0031077: post-embryonic camera-type eye development GO:0031334: positive regulation of protein complex assembly GO:0031954: positive regulation of protein autophosphorylation GO:0032147: activation of protein kinase activity GO:0032793: positive regulation of CREB transcription factor activity GO:0033138: positive regulation of peptidyl-serine phosphorylation GO:0035148: tube formation GO:0035767: endothelial cell chemotaxis GO:0035924: cellular response to vascular endothelial growth factor stimulus GO:0036303: lymph vessel morphogenesis GO:0038033: positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038091: positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0042462: eye photoreceptor cell development GO:0043117: positive regulation of vascular permeability GO:0043129: surfactant homeostasis GO:0043154: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043406: positive regulation of MAP kinase activity GO:0043536: positive regulation of blood vessel endothelial cell migration GO:0045766: positive regulation of angiogenesis GO:0045785: positive regulation of cell adhesion GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0048010: vascular endothelial growth factor receptor signaling pathway GO:0048469: cell maturation GO:0048593: camera-type eye morphogenesis GO:0048739: cardiac muscle fiber development GO:0048754: branching morphogenesis of an epithelial tube GO:0048842: positive regulation of axon extension involved in axon guidance GO:0048844: artery morphogenesis GO:0050679: positive regulation of epithelial cell proliferation GO:0050731: positive regulation of peptidyl-tyrosine phosphorylation GO:0050918: positive chemotaxis GO:0050927: positive regulation of positive chemotaxis GO:0050930: induction of positive chemotaxis GO:0051272: positive regulation of cellular component movement GO:0051781: positive regulation of cell division GO:0051894: positive regulation of focal adhesion assembly GO:0060319: primitive erythrocyte differentiation GO:0060749: mammary gland alveolus development GO:0060754: positive regulation of mast cell chemotaxis GO:0060948: cardiac vascular smooth muscle cell development GO:0060982: coronary artery morphogenesis GO:0061418: regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419: positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0071456: cellular response to hypoxia GO:0071542: dopaminergic neuron differentiation GO:0071679: commissural neuron axon guidance GO:0090037: positive regulation of protein kinase C signaling cascade GO:0090050: positive regulation of cell migration involved in sprouting angiogenesis GO:0090190: positive regulation of branching involved in ureteric bud morphogenesis GO:0090259: regulation of retinal ganglion cell axon guidance GO:1900086: positive regulation of peptidyl-tyrosine autophosphorylation GO:1900745: positive regulation of p38MAPK cascade GO:1901727: positive regulation of histone deacetylase activity GO:1902336: positive regulation of retinal ganglion cell axon guidance GO:0016020: membrane GO:0005576: extracellular region GO:0005578: proteinaceous extracellular matrix GO:0005615: extracellular space GO:0005737: cytoplasm GO:0030141: secretory granule GO:0009986: cell surface GO:0031093: platelet alpha granule lumen GO:0005515: protein binding GO:0001968: fibronectin binding GO:0005125: cytokine activity GO:0005161: platelet-derived growth factor receptor binding GO:0005172: vascular endothelial growth factor receptor binding GO:0008083: growth factor activity GO:0008201: heparin binding GO:0042802: identical protein binding GO:0048018: receptor agonist activity GO:0050840: extracellular matrix binding GO:0042056: chemoattractant activity GO:0042803: protein homodimerization activity GO:0043183: vascular endothelial growth factor receptor 1 binding GO:0043184: vascular endothelial growth factor receptor 2 binding GO:0046982: protein heterodimerization activity |
KEGG pathways |
4060: Cytokine-cytokine receptor interaction 4150: mTOR signaling pathway 4370: VEGF signaling pathway 4510: Focal adhesion 5200: Pathways in cancer 5211: Renal cell carcinoma 5212: Pancreatic cancer 5219: Bladder cancer 5323: Rheumatoid arthritis |
PMID | Title | Tumor | Value |
---|---|---|---|
7528503 | Quantitative RT-PCR assay detecting the transcriptional induction of vascular endothelial growth factor under hypoxia. | no | no |
10533453 | Cell-retained isoforms of vascular endothelial growth factor (VEGF) are correlated with poor prognosis in osteosarcoma. | yes | yes |
10690541 | Vascular endothelial growth factor expression in untreated osteosarcoma is predictive of pulmonary metastasis and poor prognosis. | yes | yes |
10891538 | Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma. | yes | yes |
11953816 | Increased pre-therapeutic serum vascular endothelial growth factor in patients with early clinical relapse of osteosarcoma. | yes | yes |
12404059 | Expression of osteopontin and vascular endothelial growth factor in benign and malignant bone tumors. | yes | no |
14598359 | Cytokine and cytokine receptor serum levels in adult bone sarcoma patients: correlations with local tumor extent and prognosis. | yes | yes |
15346048 | VEGF expression in osteosarcoma correlates with vascular permeability by dynamic MRI. | yes | yes |
15985268 | Pigment epithelium-derived factor (PEDF)-induced apoptosis and inhibition of vascular endothelial growth factor (VEGF) expression in MG63 human osteosarcoma cells. | no | no |
16119739 | Expression and significance of TGF-beta isoform and VEGF in osteosarcoma. | yes | yes |
16528367 | CXCR4 and VEGF expression in the primary site and the metastatic site of human osteosarcoma: analysis within a group of patients, all of whom developed lung metastasis. | yes | yes |
16786118 | Does the degree of intratumoural microvessel density and VEGF expression have prognostic significance in osteosarcoma? | yes | no |
16826116 | Vascular endothelial growth factor expression in osteosarcoma. | yes | yes |
17310851 | Inhibition of hypoxia-induced angiogenesis by trichostatin A via suppression of HIF-1a activity in human osteosarcoma. | no | no |
17549480 | Effect of cortisol on cell proliferation and the expression of lipoprotein lipase and vascular endothelial growth factor in a human osteosarcoma cell line. | no | no |
17690908 | Possible prognostic role of IL-17R in osteosarcoma. | no | yes |
17892509 | Vector-based Ape1 small interfering RNA enhances the sensitivity of human osteosarcoma cells to endostatin in vivo. | no | no |
17980359 | Icariside II from Epimedium koreanum inhibits hypoxia-inducible factor-1alpha in human osteosarcoma cells. | no | no |
18332870 | Cisplatin treatment increases survival and expansion of a highly tumorigenic side-population fraction by upregulating VEGF/Flt1 autocrine signaling. | no | no |
18339860 | Deletion of Yin Yang 1 protein in osteosarcoma cells on cell invasion and CXCR4/angiogenesis and metastasis. | no | no |
18438338 | VEGF-siRNA silencing induces apoptosis, inhibits proliferation and suppresses vasculogenic mimicry in osteosarcoma in vitro. | yes | no |
18528739 | Hypoxia markers in human osteosarcoma: an exploratory study. | yes | no |
18563508 | Expression of macrophage migration inhibitory factor relates to survival in high-grade osteosarcoma. | yes | no |
18771083 | VEGF165 is necessary to the metastatic potential of Fas(-) osteosarcoma cells but will not rescue the Fas(+) cells. | no | no |
18854653 | Prognostic significance of alpha V integrin and VEGF in osteosarcoma after chemotherapy. | yes | yes |
19483233 | The level of vascular endothelial growth factor as a predictor of a poor prognosis in osteosarcoma. | yes | no |
19621435 | VEGF expression as a prognostic marker in osteosarcoma. | yes | yes |
19789339 | The insulin-like growth factor-1 receptor-targeting antibody, CP-751,871, suppresses tumor-derived VEGF and synergizes with rapamycin in models of childhood sarcoma. | no | no |
19836228 | VEGF and EMMPRIN expression correlates with survival of patients with osteosarcoma. | yes | yes |
20003259 | Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways. | yes | no |
20158913 | Neoadjuvant multidrug chemotherapy including high-dose methotrexate modifies VEGF expression in osteosarcoma: an immunohistochemical analysis. | yes | yes |
20349215 | Relationships between levels of CXCR4 and VEGF and blood-borne metastasis and survival in patients with osteosarcoma. | yes | yes |
20701666 | Proliferative, apoptotic and angiogenic potentials in jaws and long bones osteosarcomas: a comparative immunohistochemical study. | yes | no |
21240382 | Expression of molecular markers in the tumor and survival prognosis in osteosarcoma. | yes | yes |
21375766 | RNAi-mediated knockdown of cyclooxygenase2 inhibits the growth, invasion and migration of SaOS2 human osteosarcoma cells: a case control study. | no | no |
21416580 | A prognostic evaluation of vascular endothelial growth factor in children and young adults with osteosarcoma. | yes | yes |
21443800 | The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. | no | no |
21481226 | Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines. | no | no |
21495021 | Genetic amplification of the vascular endothelial growth factor (VEGF) pathway genes, including VEGFA, in human osteosarcoma. | yes | yes |
21986150 | Difference in pre- and postchemotherapy vascular endothelial growth factor levels as a prognostic indicator in osteosarcoma. | yes | yes |
22274866 | The prognostic value of elevated vascular endothelial growth factor in patients with osteosarcoma: a meta-analysis and systemic review. | yes | yes |
22472569 | MicroRNA-145 targets vascular endothelial growth factor and inhibits invasion and metastasis of osteosarcoma cells. | yes | no |
22641358 | Combined administration of EGCG and IL-1 receptor antagonist efficiently downregulates IL-1-induced tumorigenic factors in U-2 OS human osteosarcoma cells. | no | no |
22855059 | Expression of Vascular Endothelial Growth Factor correlates with the advance of clinical osteosarcoma. | yes | yes |
23015149 | Role of vascular endothelial growth factor as a tumour marker in osteosarcoma: a prospective study. | yes | yes |
23219526 | Interleukin-6 induces vascular endothelial growth factor expression and promotes angiogenesis through apoptosis signal-regulating kinase 1 in human osteosarcoma. | no | no |
23167426 | Clinical predictive value of serum angiogenic factor in patients with osteosarcoma. | yes | yes |
23192273 | IL-17A/IL-17RA interaction promoted metastasis of osteosarcoma cells. | yes | no |
23403511 | Rapamycin increases pCREB, Bcl-2, and VEGF-A through ERK under normoxia. | no | no |
23430952 | Diallyl trisulfide inhibits proliferation, invasion and angiogenesis of osteosarcoma cells by switching on suppressor microRNAs and inactivating of Notch-1 signaling. | no | no |
23589053 | A systematic review of vascular endothelial growth factor expression as a biomarker of prognosis in patients with osteosarcoma. | yes | yes |
23740448 | Relaxin promotes in vitro tumour growth, invasion and angiogenesis of human Saos-2 osteosarcoma cells by AKT/VEGF pathway. | no | no |
23879172 | FIM-A, a phosphorus-containing sirolimus, inhibits the angiogenesis and proliferation of osteosarcomas. | no | no |
title | all | all |