General Information
Gene ID | 7428 |
---|---|
Gene Symbol | VHL |
Gene Name | von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase |
Gene Type | protein-coding |
Cytoband | 3p25.3 |
Ensembl ID | ENSG00000134086 |
#miR regulators | 15 |
Omim ID | 144700 171300 193300 263400 608537 |
Gene ontology |
GO:0000122: negative regulation of transcription from RNA polymerase II promoter GO:0000902: cell morphogenesis GO:0001525: angiogenesis GO:0016567: protein ubiquitination GO:0006355: regulation of transcription, DNA-dependent GO:0006508: proteolysis GO:0006950: response to stress GO:0043066: negative regulation of apoptotic process GO:0008285: negative regulation of cell proliferation GO:0010498: proteasomal protein catabolic process GO:0045893: positive regulation of transcription, DNA-dependent GO:0050821: protein stabilization GO:0030182: neuron differentiation GO:0030198: extracellular matrix organization GO:0042069: regulation of catecholamine metabolic process GO:0043534: blood vessel endothelial cell migration GO:0045471: response to ethanol GO:0045597: positive regulation of cell differentiation GO:0051291: protein heterooligomerization GO:0061418: regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061428: negative regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0071456: cellular response to hypoxia GO:0016020: membrane GO:0005739: mitochondrion GO:0005829: cytosol GO:0005783: endoplasmic reticulum GO:0005634: nucleus GO:0005654: nucleoplasm GO:0030891: VCB complex GO:0005515: protein binding GO:0004842: ubiquitin-protein ligase activity GO:0008134: transcription factor binding GO:0019899: enzyme binding GO:0032403: protein complex binding |
KEGG pathways |
4120: Ubiquitin mediated proteolysis 5200: Pathways in cancer 5211: Renal cell carcinoma |
PMID | Title | Tumor | Value |
---|---|---|---|
17980359 | Icariside II from Epimedium koreanum inhibits hypoxia-inducible factor-1alpha in human osteosarcoma cells. | no | no |
title | all | all |