Results for VHL

General Information

Gene ID 7428
Gene Symbol VHL
Gene Name von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
Gene Type protein-coding
Cytoband 3p25.3
Ensembl ID ENSG00000134086
#miR regulators 15
Omim ID 144700 171300 193300 263400 608537
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0000902: cell morphogenesis
GO:0001525: angiogenesis
GO:0016567: protein ubiquitination
GO:0006355: regulation of transcription, DNA-dependent
GO:0006508: proteolysis
GO:0006950: response to stress
GO:0043066: negative regulation of apoptotic process
GO:0008285: negative regulation of cell proliferation
GO:0010498: proteasomal protein catabolic process
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0050821: protein stabilization
GO:0030182: neuron differentiation
GO:0030198: extracellular matrix organization
GO:0042069: regulation of catecholamine metabolic process
GO:0043534: blood vessel endothelial cell migration
GO:0045471: response to ethanol
GO:0045597: positive regulation of cell differentiation
GO:0051291: protein heterooligomerization
GO:0061418: regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061428: negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456: cellular response to hypoxia
GO:0016020: membrane
GO:0005739: mitochondrion
GO:0005829: cytosol
GO:0005783: endoplasmic reticulum
GO:0005634: nucleus
GO:0005654: nucleoplasm
GO:0030891: VCB complex
GO:0005515: protein binding
GO:0004842: ubiquitin-protein ligase activity
GO:0008134: transcription factor binding
GO:0019899: enzyme binding
GO:0032403: protein complex binding
KEGG pathways 4120: Ubiquitin mediated proteolysis
5200: Pathways in cancer
5211: Renal cell carcinoma

PubMed abstracts associated with VHL

PMID Title Tumor Value
17980359 Icariside II from Epimedium koreanum inhibits hypoxia-inducible factor-1alpha in human osteosarcoma cells. no no
title all all