Results for EZR

General Information

Gene ID 7430
Gene Symbol EZR
Gene Name ezrin
Gene Type protein-coding
Cytoband 6q25.3
Ensembl ID ENSG00000092820
#miR regulators 7
Omim ID 123900
Gene ontology GO:0051017: actin filament bundle assembly
GO:0007016: cytoskeletal anchoring at plasma membrane
GO:0007159: leukocyte cell-cell adhesion
GO:0007411: axon guidance
GO:0008360: regulation of cell shape
GO:0022614: membrane to membrane docking
GO:0030855: epithelial cell differentiation
GO:0035088: establishment or maintenance of apical/basal cell polarity
GO:0005886: plasma membrane
GO:0019898: extrinsic to membrane
GO:0001726: ruffle
GO:0001931: uropod
GO:0005829: cytosol
GO:0005730: nucleolus
GO:0005884: actin filament
GO:0005902: microvillus
GO:0005925: focal adhesion
GO:0005932: microtubule basal body
GO:0015629: actin cytoskeleton
GO:0016323: basolateral plasma membrane
GO:0016324: apical plasma membrane
GO:0030175: filopodium
GO:0030863: cortical cytoskeleton
GO:0031528: microvillus membrane
GO:0032587: ruffle membrane
GO:0045177: apical part of cell
GO:0005515: protein binding
GO:0051015: actin filament binding
GO:0050839: cell adhesion molecule binding
KEGG pathways 4670: Leukocyte transendothelial migration
4810: Regulation of actin cytoskeleton
4971: Gastric acid secretion
5130: Pathogenic Escherichia coli infection

PubMed abstracts associated with EZR

PMID Title Tumor Value
14676807 Gene expression array profile of human osteosarcoma. yes no
14704791 The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. no yes
16677779 Ezrin in osteosarcoma: comparison between conventional high-grade and central low-grade osteosarcoma. yes yes
17353802 Ezrin expression predicts survival in stage IIB osteosarcomas. yes yes
17609619 High level of ezrin mRNA expression in an osteosarcoma biopsy sample with lung metastasis. yes yes
17786474 Ezrin and alpha-smooth muscle actin are immunohistochemical prognostic markers in conventional osteosarcomas. yes yes
17886294 Prognostic significance of immunohistochemical expression of ezrin in non-metastatic high-grade osteosarcoma. yes yes
19050913 Ezrin immunohistochemical expression in cartilaginous tumours: a useful tool for differential diagnosis between chondroblastic osteosarcoma and chondrosarcoma. yes yes
19060919 The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC. no no
19331807 Expression of Ezrin correlates with lung metastasis in Chinese patients with osteosarcoma. yes no
19366061 Expression of ezrin and metastatic tumor antigen in osteosarcomas of the jaw. yes yes
19492781 Proteomic analysis of chemonaive pediatric osteosarcomas and corresponding normal bone reveals multiple altered molecular targets. yes no
19597468 Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin. yes yes
20003259 Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways. yes no
20348881 Phosphorylated ezrin is located in the nucleus of the osteosarcoma cell. yes yes
20362224 Comparative proteomics analysis of human osteosarcomas and benign tumor of bone. yes yes
20562647 Immunoexpression of Ezrin and CD44 in patients with osteosarcoma. yes no
20859706 Expression change of ezrin as a prognostic factor in primary osteosarcoma. yes yes
21780101 P-glycoprotein binds to ezrin at amino acid residues 149-242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma. no no
22147261 Dysregulation of ezrin phosphorylation prevents metastasis and alters cellular metabolism in osteosarcoma. no no
22286748 siRNAs target sites selection of ezrin and the influence of RNA interference on ezrin expression and biological characters of osteosarcoma cells. no no
22525461 Down-regulation of miR-183 promotes migration and invasion of osteosarcoma by targeting Ezrin. yes no
22922800 miR-183 inhibits the metastasis of osteosarcoma via downregulation of the expression of Ezrin in F5M2 cells. no no
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