General Information
Gene ID | 7430 |
---|---|
Gene Symbol | EZR |
Gene Name | ezrin |
Gene Type | protein-coding |
Cytoband | 6q25.3 |
Ensembl ID | ENSG00000092820 |
#miR regulators | 7 |
Omim ID | 123900 |
Gene ontology |
GO:0051017: actin filament bundle assembly GO:0007016: cytoskeletal anchoring at plasma membrane GO:0007159: leukocyte cell-cell adhesion GO:0007411: axon guidance GO:0008360: regulation of cell shape GO:0022614: membrane to membrane docking GO:0030855: epithelial cell differentiation GO:0035088: establishment or maintenance of apical/basal cell polarity GO:0005886: plasma membrane GO:0019898: extrinsic to membrane GO:0001726: ruffle GO:0001931: uropod GO:0005829: cytosol GO:0005730: nucleolus GO:0005884: actin filament GO:0005902: microvillus GO:0005925: focal adhesion GO:0005932: microtubule basal body GO:0015629: actin cytoskeleton GO:0016323: basolateral plasma membrane GO:0016324: apical plasma membrane GO:0030175: filopodium GO:0030863: cortical cytoskeleton GO:0031528: microvillus membrane GO:0032587: ruffle membrane GO:0045177: apical part of cell GO:0005515: protein binding GO:0051015: actin filament binding GO:0050839: cell adhesion molecule binding |
KEGG pathways |
4670: Leukocyte transendothelial migration 4810: Regulation of actin cytoskeleton 4971: Gastric acid secretion 5130: Pathogenic Escherichia coli infection |
PMID | Title | Tumor | Value |
---|---|---|---|
14676807 | Gene expression array profile of human osteosarcoma. | yes | no |
14704791 | The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. | no | yes |
16677779 | Ezrin in osteosarcoma: comparison between conventional high-grade and central low-grade osteosarcoma. | yes | yes |
17353802 | Ezrin expression predicts survival in stage IIB osteosarcomas. | yes | yes |
17609619 | High level of ezrin mRNA expression in an osteosarcoma biopsy sample with lung metastasis. | yes | yes |
17786474 | Ezrin and alpha-smooth muscle actin are immunohistochemical prognostic markers in conventional osteosarcomas. | yes | yes |
17886294 | Prognostic significance of immunohistochemical expression of ezrin in non-metastatic high-grade osteosarcoma. | yes | yes |
19050913 | Ezrin immunohistochemical expression in cartilaginous tumours: a useful tool for differential diagnosis between chondroblastic osteosarcoma and chondrosarcoma. | yes | yes |
19060919 | The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC. | no | no |
19331807 | Expression of Ezrin correlates with lung metastasis in Chinese patients with osteosarcoma. | yes | no |
19366061 | Expression of ezrin and metastatic tumor antigen in osteosarcomas of the jaw. | yes | yes |
19492781 | Proteomic analysis of chemonaive pediatric osteosarcomas and corresponding normal bone reveals multiple altered molecular targets. | yes | no |
19597468 | Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin. | yes | yes |
20003259 | Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways. | yes | no |
20348881 | Phosphorylated ezrin is located in the nucleus of the osteosarcoma cell. | yes | yes |
20362224 | Comparative proteomics analysis of human osteosarcomas and benign tumor of bone. | yes | yes |
20562647 | Immunoexpression of Ezrin and CD44 in patients with osteosarcoma. | yes | no |
20859706 | Expression change of ezrin as a prognostic factor in primary osteosarcoma. | yes | yes |
21780101 | P-glycoprotein binds to ezrin at amino acid residues 149-242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma. | no | no |
22147261 | Dysregulation of ezrin phosphorylation prevents metastasis and alters cellular metabolism in osteosarcoma. | no | no |
22286748 | siRNAs target sites selection of ezrin and the influence of RNA interference on ezrin expression and biological characters of osteosarcoma cells. | no | no |
22525461 | Down-regulation of miR-183 promotes migration and invasion of osteosarcoma by targeting Ezrin. | yes | no |
22922800 | miR-183 inhibits the metastasis of osteosarcoma via downregulation of the expression of Ezrin in F5M2 cells. | no | no |
title | all | all |