Results for WNT5A

General Information

Gene ID 7474
Gene Symbol WNT5A
Gene Name wingless-type MMTV integration site family, member 5A
Gene Type protein-coding
Cytoband 3p21-p14
Ensembl ID ENSG00000114251
#miR regulators 8
Omim ID 164975 180700
Gene ontology GO:0000187: activation of MAPK activity
GO:0001667: ameboidal cell migration
GO:0001736: establishment of planar polarity
GO:0001756: somitogenesis
GO:0001837: epithelial to mesenchymal transition
GO:0001843: neural tube closure
GO:0001938: positive regulation of endothelial cell proliferation
GO:0001947: heart looping
GO:0002053: positive regulation of mesenchymal cell proliferation
GO:0002088: lens development in camera-type eye
GO:0002741: positive regulation of cytokine secretion involved in immune response
GO:0003323: type B pancreatic cell development
GO:0003408: optic cup formation involved in camera-type eye development
GO:0016055: Wnt receptor signaling pathway
GO:0007223: Wnt receptor signaling pathway, calcium modulating pathway
GO:0006468: protein phosphorylation
GO:0007257: activation of JUN kinase activity
GO:0007411: axon guidance
GO:0007442: hindgut morphogenesis
GO:0007494: midgut development
GO:0043066: negative regulation of apoptotic process
GO:0008584: male gonad development
GO:0008595: anterior/posterior axis specification, embryo
GO:0010033: response to organic substance
GO:0010595: positive regulation of endothelial cell migration
GO:0010800: positive regulation of peptidyl-threonine phosphorylation
GO:0010820: positive regulation of T cell chemotaxis
GO:0010976: positive regulation of neuron projection development
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0021891: olfactory bulb interneuron development
GO:0030182: neuron differentiation
GO:0030216: keratinocyte differentiation
GO:0030324: lung development
GO:0030514: negative regulation of BMP signaling pathway
GO:0030825: positive regulation of cGMP metabolic process
GO:0032148: activation of protein kinase B activity
GO:0032729: positive regulation of interferon-gamma production
GO:0032755: positive regulation of interleukin-6 production
GO:0033138: positive regulation of peptidyl-serine phosphorylation
GO:0034613: cellular protein localization
GO:0036342: post-anal tail morphogenesis
GO:0038031: non-canonical Wnt receptor signaling pathway via JNK cascade
GO:0040037: negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042060: wound healing
GO:0042733: embryonic digit morphogenesis
GO:0043032: positive regulation of macrophage activation
GO:0045080: positive regulation of chemokine biosynthetic process
GO:0045165: cell fate commitment
GO:0045599: negative regulation of fat cell differentiation
GO:0045732: positive regulation of protein catabolic process
GO:0045766: positive regulation of angiogenesis
GO:0045778: positive regulation of ossification
GO:0045836: positive regulation of meiosis
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0046330: positive regulation of JNK cascade
GO:0048146: positive regulation of fibroblast proliferation
GO:0048706: embryonic skeletal system development
GO:0048806: genitalia development
GO:0048843: negative regulation of axon extension involved in axon guidance
GO:0048850: hypophysis morphogenesis
GO:0050680: negative regulation of epithelial cell proliferation
GO:0050718: positive regulation of interleukin-1 beta secretion
GO:0050729: positive regulation of inflammatory response
GO:0050919: negative chemotaxis
GO:0051092: positive regulation of NF-kappaB transcription factor activity
GO:0051216: cartilage development
GO:0051964: negative regulation of synapse assembly
GO:0060021: palate development
GO:0060029: convergent extension involved in organogenesis
GO:0060065: uterus development
GO:0060067: cervix development
GO:0060068: vagina development
GO:0060070: canonical Wnt receptor signaling pathway
GO:0060157: urinary bladder development
GO:0060324: face development
GO:0060340: positive regulation of type I interferon-mediated signaling pathway
GO:0060599: lateral sprouting involved in mammary gland duct morphogenesis
GO:0060638: mesenchymal-epithelial cell signaling
GO:0060686: negative regulation of prostatic bud formation
GO:0060744: mammary gland branching involved in thelarche
GO:0060750: epithelial cell proliferation involved in mammary gland duct elongation
GO:0060760: positive regulation of response to cytokine stimulus
GO:0060762: regulation of branching involved in mammary gland duct morphogenesis
GO:0060907: positive regulation of macrophage cytokine production
GO:0061036: positive regulation of cartilage development
GO:0061347: planar cell polarity pathway involved in outflow tract morphogenesis
GO:0061348: planar cell polarity pathway involved in ventricular septum morphogenesis
GO:0061349: planar cell polarity pathway involved in cardiac right atrium morphogenesis
GO:0061350: planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
GO:0061354: planar cell polarity pathway involved in pericardium morphogenesis
GO:0070245: positive regulation of thymocyte apoptotic process
GO:0071222: cellular response to lipopolysaccharide
GO:0071277: cellular response to calcium ion
GO:0071300: cellular response to retinoic acid
GO:0071346: cellular response to interferon-gamma
GO:0071425: hematopoietic stem cell proliferation
GO:0071542: dopaminergic neuron differentiation
GO:0071560: cellular response to transforming growth factor beta stimulus
GO:0072201: negative regulation of mesenchymal cell proliferation
GO:0090009: primitive streak formation
GO:0090037: positive regulation of protein kinase C signaling cascade
GO:0090090: negative regulation of canonical Wnt receptor signaling pathway
GO:0090103: cochlea morphogenesis
GO:0090179: planar cell polarity pathway involved in neural tube closure
GO:2000049: positive regulation of cell-cell adhesion mediated by cadherin
GO:2000484: positive regulation of interleukin-8 secretion
GO:0005886: plasma membrane
GO:0005576: extracellular region
GO:0005578: proteinaceous extracellular matrix
GO:0005615: extracellular space
GO:0005788: endoplasmic reticulum lumen
GO:0005796: Golgi lumen
GO:0009986: cell surface
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0005109: frizzled binding
GO:0005110: frizzled-2 binding
GO:0005115: receptor tyrosine kinase-like orphan receptor binding
GO:0005125: cytokine activity
GO:0044212: transcription regulatory region DNA binding
GO:0019904: protein domain specific binding
GO:0048018: receptor agonist activity
KEGG pathways 4310: Wnt signaling pathway
4340: Hedgehog signaling pathway
4916: Melanogenesis
5200: Pathways in cancer
5217: Basal cell carcinoma

PubMed abstracts associated with WNT5A

PMID Title Tumor Value
14669798 Biological properties and gene expression associated with metastatic potential of human osteosarcoma. no no
19561643 Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling. no no
22128168 Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP-13) expression. no no
23383046 FHL2 silencing reduces Wnt signaling and osteosarcoma tumorigenesis in vitro and in vivo. yes no
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