Results for WRN

General Information

Gene ID 7486
Gene Symbol WRN
Gene Name Werner syndrome, RecQ helicase-like
Gene Type protein-coding
Cytoband 8p12
Ensembl ID ENSG00000165392
#miR regulators 5
Omim ID 277700 604611
Gene ontology GO:0006260: DNA replication
GO:0000723: telomere maintenance
GO:0000731: DNA synthesis involved in DNA repair
GO:0001302: replicative cell aging
GO:0006200: ATP catabolic process
GO:0006259: DNA metabolic process
GO:0006284: base-excision repair
GO:0006302: double-strand break repair
GO:0006310: DNA recombination
GO:0006974: response to DNA damage stimulus
GO:0006979: response to oxidative stress
GO:0007568: aging
GO:0007569: cell aging
GO:0009267: cellular response to starvation
GO:0010225: response to UV-C
GO:0010259: multicellular organismal aging
GO:0042981: regulation of apoptotic process
GO:0031297: replication fork processing
GO:0032066: nucleolus to nucleoplasm transport
GO:0032508: DNA duplex unwinding
GO:0040009: regulation of growth rate
GO:0051345: positive regulation of hydrolase activity
GO:0071480: cellular response to gamma radiation
GO:0005634: nucleus
GO:0005654: nucleoplasm
GO:0005730: nucleolus
GO:0005813: centrosome
GO:0032389: MutLalpha complex
GO:0005515: protein binding
GO:0000287: magnesium ion binding
GO:0000403: Y-form DNA binding
GO:0000405: bubble DNA binding
GO:0003677: DNA binding
GO:0003678: DNA helicase activity
GO:0004003: ATP-dependent DNA helicase activity
GO:0004386: helicase activity
GO:0004527: exonuclease activity
GO:0005524: ATP binding
GO:0008408: 3'-5' exonuclease activity
GO:0016887: ATPase activity
GO:0009378: four-way junction helicase activity
GO:0030145: manganese ion binding
GO:0032403: protein complex binding
GO:0042803: protein homodimerization activity
GO:0043138: 3'-5' DNA helicase activity
GO:0043140: ATP-dependent 3'-5' DNA helicase activity
GO:0051880: G-quadruplex DNA binding
KEGG pathways ---

PubMed abstracts associated with WRN

PMID Title Tumor Value
19559722 Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulation of BRCA1. no no
22390926 Targeting Werner syndrome protein sensitizes U-2 OS osteosarcoma cells to selenium-induced DNA damage response and necrotic death. no no
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