General Information
Gene ID | 7490 |
---|---|
Gene Symbol | WT1 |
Gene Name | Wilms tumor 1 |
Gene Type | protein-coding |
Cytoband | 11p13 |
Ensembl ID | ENSG00000184937 |
#miR regulators | 3 |
Omim ID | 106210 136680 194070 194080 256370 607102 608978 |
Gene ontology |
GO:0000122: negative regulation of transcription from RNA polymerase II promoter GO:0001570: vasculogenesis GO:0001657: ureteric bud development GO:0001658: branching involved in ureteric bud morphogenesis GO:0001822: kidney development GO:0003156: regulation of organ formation GO:0006309: apoptotic DNA fragmentation GO:0006355: regulation of transcription, DNA-dependent GO:0006357: regulation of transcription from RNA polymerase II promoter GO:0007281: germ cell development GO:0007356: thorax and anterior abdomen determination GO:0009888: tissue development GO:0007507: heart development GO:0007530: sex determination GO:0043066: negative regulation of apoptotic process GO:0008380: RNA splicing GO:0008285: negative regulation of cell proliferation GO:0008406: gonad development GO:0008584: male gonad development GO:0009451: RNA modification GO:0045893: positive regulation of transcription, DNA-dependent GO:0045892: negative regulation of transcription, DNA-dependent GO:0017148: negative regulation of translation GO:0030308: negative regulation of cell growth GO:0030325: adrenal gland development GO:0030539: male genitalia development GO:0030855: epithelial cell differentiation GO:0032835: glomerulus development GO:0032836: glomerular basement membrane development GO:0035802: adrenal cortex formation GO:0043010: camera-type eye development GO:0060231: mesenchymal to epithelial transition GO:0060421: positive regulation of heart growth GO:0060539: diaphragm development GO:0060923: cardiac muscle cell fate commitment GO:0061032: visceral serous pericardium development GO:0071320: cellular response to cAMP GO:0071371: cellular response to gonadotropin stimulus GO:0072075: metanephric mesenchyme development GO:0072112: glomerular visceral epithelial cell differentiation GO:0072166: posterior mesonephric tubule development GO:0072207: metanephric epithelium development GO:0072284: metanephric S-shaped body morphogenesis GO:0072302: negative regulation of metanephric glomerular mesangial cell proliferation GO:2000020: positive regulation of male gonad development GO:2000195: negative regulation of female gonad development GO:2001076: positive regulation of metanephric ureteric bud development GO:0005634: nucleus GO:0005737: cytoplasm GO:0005654: nucleoplasm GO:0005730: nucleolus GO:0016607: nuclear speck GO:0005515: protein binding GO:0001077: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0003700: sequence-specific DNA binding transcription factor activity GO:0003723: RNA binding GO:0008270: zinc ion binding GO:0044212: transcription regulatory region DNA binding GO:0043565: sequence-specific DNA binding GO:0070742: C2H2 zinc finger domain binding |
KEGG pathways | --- |
PMID | Title | Tumor | Value |
---|---|---|---|
12824921 | Overexpression of the Wilms' tumor gene WT1 in human bone and soft-tissue sarcomas. | yes | no |
16547468 | Immunohistochemical detection of WT1 protein in a variety of cancer cells. | yes | no |
16857797 | High WT1 expression is associated with very poor survival of patients with osteogenic sarcoma metastasis. | yes | yes |
title | all | all |