General Information
Gene ID | 8091 |
---|---|
Gene Symbol | HMGA2 |
Gene Name | high mobility group AT-hook 2 |
Gene Type | protein-coding |
Cytoband | 12q15 |
Ensembl ID | ENSG00000149948 |
#miR regulators | 17 |
Omim ID | 150699 600698 |
Gene ontology |
GO:0000122: negative regulation of transcription from RNA polymerase II promoter GO:0001837: epithelial to mesenchymal transition GO:0002062: chondrocyte differentiation GO:0003131: mesodermal-endodermal cell signaling GO:0009615: response to virus GO:0006284: base-excision repair GO:0006325: chromatin organization GO:0006355: regulation of transcription, DNA-dependent GO:0007067: mitosis GO:0007095: mitotic G2 DNA damage checkpoint GO:0007275: multicellular organismal development GO:0007283: spermatogenesis GO:0043066: negative regulation of apoptotic process GO:0008584: male gonad development GO:0010564: regulation of cell cycle process GO:0010628: positive regulation of gene expression GO:0045893: positive regulation of transcription, DNA-dependent GO:0045892: negative regulation of transcription, DNA-dependent GO:0021846: cell proliferation in forebrain GO:0021983: pituitary gland development GO:0030261: chromosome condensation GO:0030325: adrenal gland development GO:0031052: chromosome breakage GO:0031507: heterochromatin assembly GO:0035019: somatic stem cell maintenance GO:0035978: histone H2A-S139 phosphorylation GO:0035986: senescence-associated heterochromatin focus assembly GO:0035987: endodermal cell differentiation GO:0035988: chondrocyte proliferation GO:0040018: positive regulation of multicellular organism growth GO:0042769: DNA damage response, detection of DNA damage GO:0043065: positive regulation of apoptotic process GO:0043392: negative regulation of DNA binding GO:0043922: negative regulation by host of viral transcription GO:0045444: fat cell differentiation GO:0045869: negative regulation of retroviral genome replication GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0048333: mesodermal cell differentiation GO:0048712: negative regulation of astrocyte differentiation GO:0048762: mesenchymal cell differentiation GO:0048863: stem cell differentiation GO:0051301: cell division GO:0060123: regulation of growth hormone secretion GO:0060613: fat pad development GO:0071158: positive regulation of cell cycle arrest GO:0090402: oncogene-induced senescence GO:2000036: regulation of stem cell maintenance GO:2000648: positive regulation of stem cell proliferation GO:2000679: positive regulation of transcription regulatory region DNA binding GO:2000685: positive regulation of cellular response to X-ray GO:2000774: positive regulation of cellular senescence GO:2001022: positive regulation of response to DNA damage stimulus GO:2001033: negative regulation of double-strand break repair via nonhomologous end joining GO:2001038: regulation of cellular response to drug GO:0000228: nuclear chromosome GO:0005634: nucleus GO:0032993: protein-DNA complex GO:0035985: senescence-associated heterochromatin focus GO:0071141: SMAD protein complex GO:0005515: protein binding GO:0000975: regulatory region DNA binding GO:0000988: protein binding transcription factor activity GO:0001047: core promoter binding GO:0001071: nucleic acid binding transcription factor activity GO:0001077: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001078: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0003677: DNA binding GO:0003680: AT DNA binding GO:0003906: DNA-(apurinic or apyrimidinic site) lyase activity GO:0004677: DNA-dependent protein kinase activity GO:0008134: transcription factor binding GO:0008301: DNA binding, bending GO:0031492: nucleosomal DNA binding GO:0035497: cAMP response element binding GO:0035500: MH2 domain binding GO:0035501: MH1 domain binding GO:0046332: SMAD binding GO:0051575: 5'-deoxyribose-5-phosphate lyase activity GO:0070742: C2H2 zinc finger domain binding |
KEGG pathways | --- |
PMID | Title | Tumor | Value |
---|---|---|---|
8908160 | Amplification of a rearranged form of the high-mobility group protein gene HMGIC in OsA-CI osteosarcoma cells. | no | no |
9935200 | CDK4 gene amplification in osteosarcoma: reciprocal relationship with INK4A gene alterations and mapping of 12q13 amplicons. | yes | no |
title | all | all |