Results for HMGA2

General Information

Gene ID 8091
Gene Symbol HMGA2
Gene Name high mobility group AT-hook 2
Gene Type protein-coding
Cytoband 12q15
Ensembl ID ENSG00000149948
#miR regulators 17
Omim ID 150699 600698
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0001837: epithelial to mesenchymal transition
GO:0002062: chondrocyte differentiation
GO:0003131: mesodermal-endodermal cell signaling
GO:0009615: response to virus
GO:0006284: base-excision repair
GO:0006325: chromatin organization
GO:0006355: regulation of transcription, DNA-dependent
GO:0007067: mitosis
GO:0007095: mitotic G2 DNA damage checkpoint
GO:0007275: multicellular organismal development
GO:0007283: spermatogenesis
GO:0043066: negative regulation of apoptotic process
GO:0008584: male gonad development
GO:0010564: regulation of cell cycle process
GO:0010628: positive regulation of gene expression
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0021846: cell proliferation in forebrain
GO:0021983: pituitary gland development
GO:0030261: chromosome condensation
GO:0030325: adrenal gland development
GO:0031052: chromosome breakage
GO:0031507: heterochromatin assembly
GO:0035019: somatic stem cell maintenance
GO:0035978: histone H2A-S139 phosphorylation
GO:0035986: senescence-associated heterochromatin focus assembly
GO:0035987: endodermal cell differentiation
GO:0035988: chondrocyte proliferation
GO:0040018: positive regulation of multicellular organism growth
GO:0042769: DNA damage response, detection of DNA damage
GO:0043065: positive regulation of apoptotic process
GO:0043392: negative regulation of DNA binding
GO:0043922: negative regulation by host of viral transcription
GO:0045444: fat cell differentiation
GO:0045869: negative regulation of retroviral genome replication
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048333: mesodermal cell differentiation
GO:0048712: negative regulation of astrocyte differentiation
GO:0048762: mesenchymal cell differentiation
GO:0048863: stem cell differentiation
GO:0051301: cell division
GO:0060123: regulation of growth hormone secretion
GO:0060613: fat pad development
GO:0071158: positive regulation of cell cycle arrest
GO:0090402: oncogene-induced senescence
GO:2000036: regulation of stem cell maintenance
GO:2000648: positive regulation of stem cell proliferation
GO:2000679: positive regulation of transcription regulatory region DNA binding
GO:2000685: positive regulation of cellular response to X-ray
GO:2000774: positive regulation of cellular senescence
GO:2001022: positive regulation of response to DNA damage stimulus
GO:2001033: negative regulation of double-strand break repair via nonhomologous end joining
GO:2001038: regulation of cellular response to drug
GO:0000228: nuclear chromosome
GO:0005634: nucleus
GO:0032993: protein-DNA complex
GO:0035985: senescence-associated heterochromatin focus
GO:0071141: SMAD protein complex
GO:0005515: protein binding
GO:0000975: regulatory region DNA binding
GO:0000988: protein binding transcription factor activity
GO:0001047: core promoter binding
GO:0001071: nucleic acid binding transcription factor activity
GO:0001077: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677: DNA binding
GO:0003680: AT DNA binding
GO:0003906: DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004677: DNA-dependent protein kinase activity
GO:0008134: transcription factor binding
GO:0008301: DNA binding, bending
GO:0031492: nucleosomal DNA binding
GO:0035497: cAMP response element binding
GO:0035500: MH2 domain binding
GO:0035501: MH1 domain binding
GO:0046332: SMAD binding
GO:0051575: 5'-deoxyribose-5-phosphate lyase activity
GO:0070742: C2H2 zinc finger domain binding
KEGG pathways ---

PubMed abstracts associated with HMGA2

PMID Title Tumor Value
8908160 Amplification of a rearranged form of the high-mobility group protein gene HMGIC in OsA-CI osteosarcoma cells. no no
9935200 CDK4 gene amplification in osteosarcoma: reciprocal relationship with INK4A gene alterations and mapping of 12q13 amplicons. yes no
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