Results for AXIN2

General Information

Gene ID 8313
Gene Symbol AXIN2
Gene Name axin 2
Gene Type protein-coding
Cytoband 17q23-q24
Ensembl ID ENSG00000168646
#miR regulators 18
Omim ID 114500 604025 608615
Gene ontology GO:0001934: positive regulation of protein phosphorylation
GO:0001957: intramembranous ossification
GO:0003413: chondrocyte differentiation involved in endochondral bone morphogenesis
GO:0008219: cell death
GO:0008283: cell proliferation
GO:0008285: negative regulation of cell proliferation
GO:0009950: dorsal/ventral axis specification
GO:0010718: positive regulation of epithelial to mesenchymal transition
GO:0010942: positive regulation of cell death
GO:0030282: bone mineralization
GO:0032423: regulation of mismatch repair
GO:0034613: cellular protein localization
GO:0035414: negative regulation of catenin import into nucleus
GO:0038032: termination of G-protein coupled receptor signaling pathway
GO:0042476: odontogenesis
GO:0043547: positive regulation of GTPase activity
GO:0043570: maintenance of DNA repeat elements
GO:0045668: negative regulation of osteoblast differentiation
GO:0045860: positive regulation of protein kinase activity
GO:0048255: mRNA stabilization
GO:0061181: regulation of chondrocyte development
GO:0070602: regulation of centromeric sister chromatid cohesion
GO:0071407: cellular response to organic cyclic compound
GO:0090090: negative regulation of canonical Wnt receptor signaling pathway
GO:0090244: Wnt receptor signaling pathway involved in somitogenesis
GO:2000054: negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification
GO:0005886: plasma membrane
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005813: centrosome
GO:0005881: cytoplasmic microtubule
GO:0005938: cell cortex
GO:0014069: postsynaptic density
GO:0016023: cytoplasmic membrane-bounded vesicle
GO:0030877: beta-catenin destruction complex
GO:0004871: signal transducer activity
GO:0005096: GTPase activator activity
GO:0008013: beta-catenin binding
GO:0019899: enzyme binding
GO:0019901: protein kinase binding
GO:0031625: ubiquitin protein ligase binding
GO:0070016: armadillo repeat domain binding
GO:0070411: I-SMAD binding
KEGG pathways 4310: Wnt signaling pathway
5200: Pathways in cancer
5210: Colorectal cancer
5213: Endometrial cancer
5217: Basal cell carcinoma

PubMed abstracts associated with AXIN2

PMID Title Tumor Value
19882675 Inactive Wnt/beta-catenin pathway in conventional high-grade osteosarcoma. yes no
title all all