General Information
Gene ID | 8313 |
---|---|
Gene Symbol | AXIN2 |
Gene Name | axin 2 |
Gene Type | protein-coding |
Cytoband | 17q23-q24 |
Ensembl ID | ENSG00000168646 |
#miR regulators | 18 |
Omim ID | 114500 604025 608615 |
Gene ontology |
GO:0001934: positive regulation of protein phosphorylation GO:0001957: intramembranous ossification GO:0003413: chondrocyte differentiation involved in endochondral bone morphogenesis GO:0008219: cell death GO:0008283: cell proliferation GO:0008285: negative regulation of cell proliferation GO:0009950: dorsal/ventral axis specification GO:0010718: positive regulation of epithelial to mesenchymal transition GO:0010942: positive regulation of cell death GO:0030282: bone mineralization GO:0032423: regulation of mismatch repair GO:0034613: cellular protein localization GO:0035414: negative regulation of catenin import into nucleus GO:0038032: termination of G-protein coupled receptor signaling pathway GO:0042476: odontogenesis GO:0043547: positive regulation of GTPase activity GO:0043570: maintenance of DNA repeat elements GO:0045668: negative regulation of osteoblast differentiation GO:0045860: positive regulation of protein kinase activity GO:0048255: mRNA stabilization GO:0061181: regulation of chondrocyte development GO:0070602: regulation of centromeric sister chromatid cohesion GO:0071407: cellular response to organic cyclic compound GO:0090090: negative regulation of canonical Wnt receptor signaling pathway GO:0090244: Wnt receptor signaling pathway involved in somitogenesis GO:2000054: negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification GO:0005886: plasma membrane GO:0005634: nucleus GO:0005737: cytoplasm GO:0005813: centrosome GO:0005881: cytoplasmic microtubule GO:0005938: cell cortex GO:0014069: postsynaptic density GO:0016023: cytoplasmic membrane-bounded vesicle GO:0030877: beta-catenin destruction complex GO:0004871: signal transducer activity GO:0005096: GTPase activator activity GO:0008013: beta-catenin binding GO:0019899: enzyme binding GO:0019901: protein kinase binding GO:0031625: ubiquitin protein ligase binding GO:0070016: armadillo repeat domain binding GO:0070411: I-SMAD binding |
KEGG pathways |
4310: Wnt signaling pathway 5200: Pathways in cancer 5210: Colorectal cancer 5213: Endometrial cancer 5217: Basal cell carcinoma |
PMID | Title | Tumor | Value |
---|---|---|---|
19882675 | Inactive Wnt/beta-catenin pathway in conventional high-grade osteosarcoma. | yes | no |
title | all | all |