General Information
Gene ID | 834 |
---|---|
Gene Symbol | CASP1 |
Gene Name | caspase 1, apoptosis-related cysteine peptidase |
Gene Type | protein-coding |
Cytoband | 11q23 |
Ensembl ID | ENSG00000137752 |
#miR regulators | 4 |
Omim ID | 147678 |
Gene ontology |
GO:0001666: response to hypoxia GO:0006915: apoptotic process GO:0007165: signal transduction GO:0006508: proteolysis GO:0016485: protein processing GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0071260: cellular response to mechanical stimulus GO:0032611: interleukin-1 beta production GO:0033198: response to ATP GO:0035872: nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0045087: innate immune response GO:0050717: positive regulation of interleukin-1 alpha secretion GO:0050718: positive regulation of interleukin-1 beta secretion GO:0051882: mitochondrial depolarization GO:0060081: membrane hyperpolarization GO:0071310: cellular response to organic substance GO:0005576: extracellular region GO:0005829: cytosol GO:0072557: IPAF inflammasome complex GO:0072558: NLRP1 inflammasome complex GO:0072559: NLRP3 inflammasome complex GO:0097169: AIM2 inflammasome complex GO:0005515: protein binding GO:0004197: cysteine-type endopeptidase activity GO:0008656: cysteine-type endopeptidase activator activity involved in apoptotic process |
KEGG pathways |
4621: NOD-like receptor signaling pathway 4623: Cytosolic DNA-sensing pathway 5014: Amyotrophic lateral sclerosis (ALS) |
PMID | Title | Tumor | Value |
---|---|---|---|
12168884 | Serum concentrations of APO-1/Fas and interleukin-1beta-converting enzyme in osteosarcoma correlate with response to chemotherapy. | yes | yes |
18414033 | Downregulation of c-jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model. | no | no |
title | all | all |