Results for CASP1

General Information

Gene ID 834
Gene Symbol CASP1
Gene Name caspase 1, apoptosis-related cysteine peptidase
Gene Type protein-coding
Cytoband 11q23
Ensembl ID ENSG00000137752
#miR regulators 4
Omim ID 147678
Gene ontology GO:0001666: response to hypoxia
GO:0006915: apoptotic process
GO:0007165: signal transduction
GO:0006508: proteolysis
GO:0016485: protein processing
GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0071260: cellular response to mechanical stimulus
GO:0032611: interleukin-1 beta production
GO:0033198: response to ATP
GO:0035872: nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0045087: innate immune response
GO:0050717: positive regulation of interleukin-1 alpha secretion
GO:0050718: positive regulation of interleukin-1 beta secretion
GO:0051882: mitochondrial depolarization
GO:0060081: membrane hyperpolarization
GO:0071310: cellular response to organic substance
GO:0005576: extracellular region
GO:0005829: cytosol
GO:0072557: IPAF inflammasome complex
GO:0072558: NLRP1 inflammasome complex
GO:0072559: NLRP3 inflammasome complex
GO:0097169: AIM2 inflammasome complex
GO:0005515: protein binding
GO:0004197: cysteine-type endopeptidase activity
GO:0008656: cysteine-type endopeptidase activator activity involved in apoptotic process
KEGG pathways 4621: NOD-like receptor signaling pathway
4623: Cytosolic DNA-sensing pathway
5014: Amyotrophic lateral sclerosis (ALS)

PubMed abstracts associated with CASP1

PMID Title Tumor Value
12168884 Serum concentrations of APO-1/Fas and interleukin-1beta-converting enzyme in osteosarcoma correlate with response to chemotherapy. yes yes
18414033 Downregulation of c-jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model. no no
title all all