Results for CASP3

General Information

Gene ID 836
Gene Symbol CASP3
Gene Name caspase 3, apoptosis-related cysteine peptidase
Gene Type protein-coding
Cytoband 4q34
Ensembl ID ENSG00000164305
#miR regulators 10
Omim ID 600636
Gene ontology GO:0001782: B cell homeostasis
GO:0001836: release of cytochrome c from mitochondria
GO:0006915: apoptotic process
GO:0006309: apoptotic DNA fragmentation
GO:0006508: proteolysis
GO:0016485: protein processing
GO:0006921: cellular component disassembly involved in execution phase of apoptosis
GO:0006974: response to DNA damage stimulus
GO:0007507: heart development
GO:0007605: sensory perception of sound
GO:0043066: negative regulation of apoptotic process
GO:0008625: extrinsic apoptotic signaling pathway via death domain receptors
GO:0008631: intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008635: activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0009411: response to UV
GO:0009611: response to wounding
GO:0042981: regulation of apoptotic process
GO:0030216: keratinocyte differentiation
GO:0030264: nuclear fragmentation involved in apoptotic nuclear change
GO:0030889: negative regulation of B cell proliferation
GO:0034612: response to tumor necrosis factor
GO:0035329: hippo signaling cascade
GO:0043029: T cell homeostasis
GO:0043065: positive regulation of apoptotic process
GO:0043281: regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043525: positive regulation of neuron apoptotic process
GO:0045165: cell fate commitment
GO:0045736: negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0046007: negative regulation of activated T cell proliferation
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0051402: neuron apoptotic process
GO:0097190: apoptotic signaling pathway
GO:0097193: intrinsic apoptotic signaling pathway
GO:0097194: execution phase of apoptosis
GO:0005886: plasma membrane
GO:0005739: mitochondrion
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005515: protein binding
GO:0004197: cysteine-type endopeptidase activity
GO:0004190: aspartic-type endopeptidase activity
GO:0008233: peptidase activity
GO:0004861: cyclin-dependent protein serine/threonine kinase inhibitor activity
KEGG pathways 4010: MAPK signaling pathway
4115: p53 signaling pathway
4210: Apoptosis
4650: Natural killer cell mediated cytotoxicity
5010: Alzheimer's disease
5012: Parkinson's disease
5014: Amyotrophic lateral sclerosis (ALS)
5016: Huntington's disease
5120: Epithelial cell signaling in Helicobacter pylori infection
5145: Toxoplasmosis
5146: Amoebiasis
5200: Pathways in cancer
5210: Colorectal cancer
5416: Viral myocarditis

PubMed abstracts associated with CASP3

PMID Title Tumor Value
10232607 Poly(ADP-ribosyl)ation of p53 during apoptosis in human osteosarcoma cells. no no
10663637 Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma. no no
10702275 Lack of oxidative phosphorylation and low mitochondrial membrane potential decrease susceptibility to apoptosis and do not modulate the protective effect of Bcl-x(L) in osteosarcoma cells. no no
11289134 Selective sensitization of retinoblastoma protein-deficient sarcoma cells to doxorubicin by flavopiridol-mediated inhibition of cyclin-dependent kinase 2 kinase activity. no no
11306692 The novel triterpenoid CDDO induces apoptosis and differentiation of human osteosarcoma cells by a caspase-8 dependent mechanism. no no
11418138 pRb suppresses camptothecin-induced apoptosis in human osteosarcoma Saos-2 cells by inhibiting c-Jun N-terminal kinase. no no
11992538 Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to Apo2L/TRAIL-induced apoptosis. no no
12616540 Alpha 4 integrin increases anoikis of human osteosarcoma cells. yes no
12919886 Chemotherapeutic agents sensitize sarcoma cell lines to tumor necrosis factor-related apoptosis-inducing ligand-induced caspase-8 activation, apoptosis and loss of mitochondrial membrane potential. no no
14647441 FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells. no no
15314286 Mechanism of histone deacetylase inhibitor Trichostatin A induced apoptosis in human osteosarcoma cells. no no
15662138 The tumor suppressor p33ING1b enhances taxol-induced apoptosis by p53-dependent pathway in human osteosarcoma U2OS cells. no no
15816563 Induction of apoptosis by sodium fluorosilicate treatment in human osteogenic sarcoma (HOS) cells. no no
15912538 CTLA-4 is constitutively expressed on tumor cells and can trigger apoptosis upon ligand interaction. yes no
15965098 Enhancement of cisplatin-induced apoptosis and caspase 3 activation by depletion of mitochondrial DNA in a human osteosarcoma cell line. no no
15985268 Pigment epithelium-derived factor (PEDF)-induced apoptosis and inhibition of vascular endothelial growth factor (VEGF) expression in MG63 human osteosarcoma cells. no no
16026999 Bacterial redox protein azurin induce apoptosis in human osteosarcoma U2OS cells. no no
16140185 Paclitaxel induces apoptosis via caspase-3 activation in human osteogenic sarcoma cells (U-2 OS). no no
16466985 Recombinant antisense C-myc adenovirus increase in vitro sensitivity of osteosarcoma MG-63 cells to cisplatin. no no
16571651 Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells. no no
16797629 Green tea polyphenols-induced apoptosis in human osteosarcoma SAOS-2 cells involves a caspase-dependent mechanism with downregulation of nuclear factor-kappaB. no no
17218775 Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cells. no no
17218778 Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells. no no
17222495 Anandamide-induced Ca2+ elevation leading to p38 MAPK phosphorylation and subsequent cell death via apoptosis in human osteosarcoma cells. no no
17471233 Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53. no no
17520676 Cyclin-dependent kinase inhibitor, flavopiridol, induces apoptosis and inhibits tumor growth in drug-resistant osteosarcoma and Ewing's family tumor cells. no no
17959036 Interferon-alpha enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin by p53-dependent apoptosis. no no
18986328 Desipramine-induced Ca-independent apoptosis in Mg63 human osteosarcoma cells: dependence on P38 mitogen-activated protein kinase-regulated activation of caspase 3. no no
19018758 Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma. no no
19229591 Lentivirus-mediated RNAi knockdown of insulin-like growth factor-1 receptor inhibits growth, reduces invasion, and enhances radiosensitivity in human osteosarcoma cells. no no
19746447 Runx2-mediated bcl-2 gene expression contributes to nitric oxide protection against hydrogen peroxide-induced osteoblast apoptosis. no no
19757179 beta-Ionone-induced apoptosis in human osteosarcoma (U2os) cells occurs via a p53-dependent signaling pathway. no no
20041491 Ionizing radiation enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulations of death receptor 4 (DR4) and death receptor 5 (DR5) in human osteosarcoma cells. no no
20044614 Curcumin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. no no
20376536 Lentivirus-mediated shRNA targeting insulin-like growth factor-1 receptor (IGF-1R) enhances chemosensitivity of osteosarcoma cells in vitro and in vivo. no no
20459702 Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway. yes no
20512478 Induction of G(1)/S phase arrest and apoptosis by quercetin in human osteosarcoma cells. no no
20580954 Functional and biological analysis of Bcl-xL expression in human osteosarcoma. yes no
21163271 Solamargine induces apoptosis associated with p53 transcription-dependent and transcription-independent pathways in human osteosarcoma U2OS cells. no no
21234653 Anti-tumor effects of dihydroartemisinin on human osteosarcoma. no no
21246613 Inhibition of mTOR signaling by oleanolic acid contributes to its anti-tumor activity in osteosarcoma cells. no no
21266106 Depletion of Neuroguidin/CANu1 sensitizes human osteosarcoma U2OS cells to doxorubicin. no no
21286665 Down-regulation of XIAP by AEG35156 in paediatric tumour cells induces apoptosis and sensitises cells to cytotoxic agents. no no
21443800 The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. no no
21573491 Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. no no
21617882 Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt. no no
21717192 Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2. no no
21805050 Quercetin-mediated apoptosis via activation of the mitochondrial-dependent pathway in MG-63 osteosarcoma cells. no no
21822538 p53 siRNA inhibits apoptosis of U2OS cells treated with azurin. no no
21826611 Sodium selenite-induced apoptosis mediated by ROS attack in human osteosarcoma U2OS cells. no no
21901524 Knockdown of Mad2 induces osteosarcoma cell apoptosis-involved Rad21 cleavage. no no
21964477 Okadaic acid induces apoptosis through the PKR, NF-?B and caspase pathway in human osteoblastic osteosarcoma MG63 cells. no no
21993662 Plumbagin induces apoptosis via the p53 pathway and generation of reactive oxygen species in human osteosarcoma cells. no no
22009832 Apoptotic effects of curcumin on human osteosarcoma U2OS cells. no no
22012179 Simvastatin protects human osteosarcoma cells from oxidative stress-induced apoptosis through mitochondrial-mediated signaling. no no
22057483 RIP3 expression induces a death profile change in U2OS osteosarcoma cells after 5-ALA-PDT. no no
22126901 Tanshinone IIA induces apoptosis and inhibits the proliferation, migration, and invasion of the osteosarcoma MG-63 cell line in vitro. no no
22231496 Daphnoretin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. no no
22246399 Millimeter wave treatment induces apoptosis via activation of the mitochondrial-dependent pathway in human osteosarcoma cells. no no
22674530 Inorganic phosphate enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin via a p53-dependent pathway. no no
22886393 TRAF6 regulates proliferation, apoptosis, and invasion of osteosarcoma cell. yes no
22922684 The cyclooxygenase-2 inhibitor NS-398 inhibits proliferation and induces apoptosis in human osteosarcoma cells via downregulation of the survivin pathway. yes no
22994717 LY294002 induces G0/G1 cell cycle arrest and apoptosis of cancer stem-like cells from human osteosarcoma via down-regulation of PI3K activity. no no
23108792 SASH1 regulates proliferation, apoptosis, and invasion of osteosarcoma cell. no no
23313376 Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway. no no
23451817 Metformin synergistically enhances antitumor activity of histone deacetylase inhibitor trichostatin a against osteosarcoma cell line. no no
23232982 Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-?B pathway. no no
23266503 Effects of baicalein on apoptosis, cell cycle arrest, migration and invasion of osteosarcoma cells. no no
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