General Information
Gene ID | 836 |
---|---|
Gene Symbol | CASP3 |
Gene Name | caspase 3, apoptosis-related cysteine peptidase |
Gene Type | protein-coding |
Cytoband | 4q34 |
Ensembl ID | ENSG00000164305 |
#miR regulators | 10 |
Omim ID | 600636 |
Gene ontology |
GO:0001782: B cell homeostasis GO:0001836: release of cytochrome c from mitochondria GO:0006915: apoptotic process GO:0006309: apoptotic DNA fragmentation GO:0006508: proteolysis GO:0016485: protein processing GO:0006921: cellular component disassembly involved in execution phase of apoptosis GO:0006974: response to DNA damage stimulus GO:0007507: heart development GO:0007605: sensory perception of sound GO:0043066: negative regulation of apoptotic process GO:0008625: extrinsic apoptotic signaling pathway via death domain receptors GO:0008631: intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008635: activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0009411: response to UV GO:0009611: response to wounding GO:0042981: regulation of apoptotic process GO:0030216: keratinocyte differentiation GO:0030264: nuclear fragmentation involved in apoptotic nuclear change GO:0030889: negative regulation of B cell proliferation GO:0034612: response to tumor necrosis factor GO:0035329: hippo signaling cascade GO:0043029: T cell homeostasis GO:0043065: positive regulation of apoptotic process GO:0043281: regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043525: positive regulation of neuron apoptotic process GO:0045165: cell fate commitment GO:0045736: negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0046007: negative regulation of activated T cell proliferation GO:0048011: neurotrophin TRK receptor signaling pathway GO:0051402: neuron apoptotic process GO:0097190: apoptotic signaling pathway GO:0097193: intrinsic apoptotic signaling pathway GO:0097194: execution phase of apoptosis GO:0005886: plasma membrane GO:0005739: mitochondrion GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0005654: nucleoplasm GO:0005515: protein binding GO:0004197: cysteine-type endopeptidase activity GO:0004190: aspartic-type endopeptidase activity GO:0008233: peptidase activity GO:0004861: cyclin-dependent protein serine/threonine kinase inhibitor activity |
KEGG pathways |
4010: MAPK signaling pathway 4115: p53 signaling pathway 4210: Apoptosis 4650: Natural killer cell mediated cytotoxicity 5010: Alzheimer's disease 5012: Parkinson's disease 5014: Amyotrophic lateral sclerosis (ALS) 5016: Huntington's disease 5120: Epithelial cell signaling in Helicobacter pylori infection 5145: Toxoplasmosis 5146: Amoebiasis 5200: Pathways in cancer 5210: Colorectal cancer 5416: Viral myocarditis |
PMID | Title | Tumor | Value |
---|---|---|---|
10232607 | Poly(ADP-ribosyl)ation of p53 during apoptosis in human osteosarcoma cells. | no | no |
10663637 | Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma. | no | no |
10702275 | Lack of oxidative phosphorylation and low mitochondrial membrane potential decrease susceptibility to apoptosis and do not modulate the protective effect of Bcl-x(L) in osteosarcoma cells. | no | no |
11289134 | Selective sensitization of retinoblastoma protein-deficient sarcoma cells to doxorubicin by flavopiridol-mediated inhibition of cyclin-dependent kinase 2 kinase activity. | no | no |
11306692 | The novel triterpenoid CDDO induces apoptosis and differentiation of human osteosarcoma cells by a caspase-8 dependent mechanism. | no | no |
11418138 | pRb suppresses camptothecin-induced apoptosis in human osteosarcoma Saos-2 cells by inhibiting c-Jun N-terminal kinase. | no | no |
11992538 | Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to Apo2L/TRAIL-induced apoptosis. | no | no |
12616540 | Alpha 4 integrin increases anoikis of human osteosarcoma cells. | yes | no |
12919886 | Chemotherapeutic agents sensitize sarcoma cell lines to tumor necrosis factor-related apoptosis-inducing ligand-induced caspase-8 activation, apoptosis and loss of mitochondrial membrane potential. | no | no |
14647441 | FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells. | no | no |
15314286 | Mechanism of histone deacetylase inhibitor Trichostatin A induced apoptosis in human osteosarcoma cells. | no | no |
15662138 | The tumor suppressor p33ING1b enhances taxol-induced apoptosis by p53-dependent pathway in human osteosarcoma U2OS cells. | no | no |
15816563 | Induction of apoptosis by sodium fluorosilicate treatment in human osteogenic sarcoma (HOS) cells. | no | no |
15912538 | CTLA-4 is constitutively expressed on tumor cells and can trigger apoptosis upon ligand interaction. | yes | no |
15965098 | Enhancement of cisplatin-induced apoptosis and caspase 3 activation by depletion of mitochondrial DNA in a human osteosarcoma cell line. | no | no |
15985268 | Pigment epithelium-derived factor (PEDF)-induced apoptosis and inhibition of vascular endothelial growth factor (VEGF) expression in MG63 human osteosarcoma cells. | no | no |
16026999 | Bacterial redox protein azurin induce apoptosis in human osteosarcoma U2OS cells. | no | no |
16140185 | Paclitaxel induces apoptosis via caspase-3 activation in human osteogenic sarcoma cells (U-2 OS). | no | no |
16466985 | Recombinant antisense C-myc adenovirus increase in vitro sensitivity of osteosarcoma MG-63 cells to cisplatin. | no | no |
16571651 | Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells. | no | no |
16797629 | Green tea polyphenols-induced apoptosis in human osteosarcoma SAOS-2 cells involves a caspase-dependent mechanism with downregulation of nuclear factor-kappaB. | no | no |
17218775 | Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cells. | no | no |
17218778 | Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells. | no | no |
17222495 | Anandamide-induced Ca2+ elevation leading to p38 MAPK phosphorylation and subsequent cell death via apoptosis in human osteosarcoma cells. | no | no |
17471233 | Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53. | no | no |
17520676 | Cyclin-dependent kinase inhibitor, flavopiridol, induces apoptosis and inhibits tumor growth in drug-resistant osteosarcoma and Ewing's family tumor cells. | no | no |
17959036 | Interferon-alpha enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin by p53-dependent apoptosis. | no | no |
18986328 | Desipramine-induced Ca-independent apoptosis in Mg63 human osteosarcoma cells: dependence on P38 mitogen-activated protein kinase-regulated activation of caspase 3. | no | no |
19018758 | Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma. | no | no |
19229591 | Lentivirus-mediated RNAi knockdown of insulin-like growth factor-1 receptor inhibits growth, reduces invasion, and enhances radiosensitivity in human osteosarcoma cells. | no | no |
19746447 | Runx2-mediated bcl-2 gene expression contributes to nitric oxide protection against hydrogen peroxide-induced osteoblast apoptosis. | no | no |
19757179 | beta-Ionone-induced apoptosis in human osteosarcoma (U2os) cells occurs via a p53-dependent signaling pathway. | no | no |
20041491 | Ionizing radiation enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulations of death receptor 4 (DR4) and death receptor 5 (DR5) in human osteosarcoma cells. | no | no |
20044614 | Curcumin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. | no | no |
20376536 | Lentivirus-mediated shRNA targeting insulin-like growth factor-1 receptor (IGF-1R) enhances chemosensitivity of osteosarcoma cells in vitro and in vivo. | no | no |
20459702 | Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway. | yes | no |
20512478 | Induction of G(1)/S phase arrest and apoptosis by quercetin in human osteosarcoma cells. | no | no |
20580954 | Functional and biological analysis of Bcl-xL expression in human osteosarcoma. | yes | no |
21163271 | Solamargine induces apoptosis associated with p53 transcription-dependent and transcription-independent pathways in human osteosarcoma U2OS cells. | no | no |
21234653 | Anti-tumor effects of dihydroartemisinin on human osteosarcoma. | no | no |
21246613 | Inhibition of mTOR signaling by oleanolic acid contributes to its anti-tumor activity in osteosarcoma cells. | no | no |
21266106 | Depletion of Neuroguidin/CANu1 sensitizes human osteosarcoma U2OS cells to doxorubicin. | no | no |
21286665 | Down-regulation of XIAP by AEG35156 in paediatric tumour cells induces apoptosis and sensitises cells to cytotoxic agents. | no | no |
21443800 | The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. | no | no |
21573491 | Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. | no | no |
21617882 | Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt. | no | no |
21717192 | Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2. | no | no |
21805050 | Quercetin-mediated apoptosis via activation of the mitochondrial-dependent pathway in MG-63 osteosarcoma cells. | no | no |
21822538 | p53 siRNA inhibits apoptosis of U2OS cells treated with azurin. | no | no |
21826611 | Sodium selenite-induced apoptosis mediated by ROS attack in human osteosarcoma U2OS cells. | no | no |
21901524 | Knockdown of Mad2 induces osteosarcoma cell apoptosis-involved Rad21 cleavage. | no | no |
21964477 | Okadaic acid induces apoptosis through the PKR, NF-κB and caspase pathway in human osteoblastic osteosarcoma MG63 cells. | no | no |
21993662 | Plumbagin induces apoptosis via the p53 pathway and generation of reactive oxygen species in human osteosarcoma cells. | no | no |
22009832 | Apoptotic effects of curcumin on human osteosarcoma U2OS cells. | no | no |
22012179 | Simvastatin protects human osteosarcoma cells from oxidative stress-induced apoptosis through mitochondrial-mediated signaling. | no | no |
22057483 | RIP3 expression induces a death profile change in U2OS osteosarcoma cells after 5-ALA-PDT. | no | no |
22126901 | Tanshinone IIA induces apoptosis and inhibits the proliferation, migration, and invasion of the osteosarcoma MG-63 cell line in vitro. | no | no |
22231496 | Daphnoretin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. | no | no |
22246399 | Millimeter wave treatment induces apoptosis via activation of the mitochondrial-dependent pathway in human osteosarcoma cells. | no | no |
22674530 | Inorganic phosphate enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin via a p53-dependent pathway. | no | no |
22886393 | TRAF6 regulates proliferation, apoptosis, and invasion of osteosarcoma cell. | yes | no |
22922684 | The cyclooxygenase-2 inhibitor NS-398 inhibits proliferation and induces apoptosis in human osteosarcoma cells via downregulation of the survivin pathway. | yes | no |
22994717 | LY294002 induces G0/G1 cell cycle arrest and apoptosis of cancer stem-like cells from human osteosarcoma via down-regulation of PI3K activity. | no | no |
23108792 | SASH1 regulates proliferation, apoptosis, and invasion of osteosarcoma cell. | no | no |
23313376 | Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway. | no | no |
23451817 | Metformin synergistically enhances antitumor activity of histone deacetylase inhibitor trichostatin a against osteosarcoma cell line. | no | no |
23232982 | Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-κB pathway. | no | no |
23266503 | Effects of baicalein on apoptosis, cell cycle arrest, migration and invasion of osteosarcoma cells. | no | no |
title | all | all |