Results for CASP8

General Information

Gene ID 841
Gene Symbol CASP8
Gene Name caspase 8, apoptosis-related cysteine peptidase
Gene Type protein-coding
Cytoband 2q33-q34
Ensembl ID ENSG00000064012
#miR regulators 19
Omim ID 114480 114550 211980 601763 607271
Gene ontology GO:0001525: angiogenesis
GO:0001841: neural tube formation
GO:0002224: toll-like receptor signaling pathway
GO:0002756: MyD88-independent toll-like receptor signaling pathway
GO:0006915: apoptotic process
GO:0006508: proteolysis
GO:0051603: proteolysis involved in cellular protein catabolic process
GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006921: cellular component disassembly involved in execution phase of apoptosis
GO:0007507: heart development
GO:0009409: response to cold
GO:0046677: response to antibiotic
GO:0019048: modulation by virus of host morphology or physiology
GO:0071260: cellular response to mechanical stimulus
GO:0030225: macrophage differentiation
GO:0032025: response to cobalt ion
GO:0032355: response to estradiol stimulus
GO:0032496: response to lipopolysaccharide
GO:0034138: toll-like receptor 3 signaling pathway
GO:0034142: toll-like receptor 4 signaling pathway
GO:0034612: response to tumor necrosis factor
GO:0035666: TRIF-dependent toll-like receptor signaling pathway
GO:0035872: nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043124: negative regulation of I-kappaB kinase/NF-kappaB cascade
GO:0045087: innate immune response
GO:0045471: response to ethanol
GO:0045651: positive regulation of macrophage differentiation
GO:0045862: positive regulation of proteolysis
GO:0051291: protein heterooligomerization
GO:0070423: nucleotide-binding oligomerization domain containing signaling pathway
GO:0097190: apoptotic signaling pathway
GO:0097191: extrinsic apoptotic signaling pathway
GO:0097193: intrinsic apoptotic signaling pathway
GO:0097202: activation of cysteine-type endopeptidase activity
GO:1900740: positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:2001239: regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0005739: mitochondrion
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005741: mitochondrial outer membrane
GO:0005813: centrosome
GO:0005856: cytoskeleton
GO:0043005: neuron projection
GO:0030690: Noc1p-Noc2p complex
GO:0031264: death-inducing signaling complex
GO:0031265: CD95 death-inducing signaling complex
GO:0044297: cell body
GO:0045121: membrane raft
GO:0005515: protein binding
GO:0004197: cysteine-type endopeptidase activity
GO:0002020: protease binding
GO:0008234: cysteine-type peptidase activity
GO:0005164: tumor necrosis factor receptor binding
GO:0042802: identical protein binding
KEGG pathways 4115: p53 signaling pathway
4210: Apoptosis
4620: Toll-like receptor signaling pathway
4621: NOD-like receptor signaling pathway
4622: RIG-I-like receptor signaling pathway
5010: Alzheimer's disease
5016: Huntington's disease
5142: Chagas disease (American trypanosomiasis)
5145: Toxoplasmosis
5200: Pathways in cancer
5416: Viral myocarditis

PubMed abstracts associated with CASP8

PMID Title Tumor Value
10663637 Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma. no no
11093825 Cisplatin (CDDP) sensitizes human osteosarcoma cell to Fas/CD95-mediated apoptosis by down-regulating FLIP-L expression. no no
11306692 The novel triterpenoid CDDO induces apoptosis and differentiation of human osteosarcoma cells by a caspase-8 dependent mechanism. no no
11992538 Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to Apo2L/TRAIL-induced apoptosis. no no
12919886 Chemotherapeutic agents sensitize sarcoma cell lines to tumor necrosis factor-related apoptosis-inducing ligand-induced caspase-8 activation, apoptosis and loss of mitochondrial membrane potential. no no
14647441 FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells. no no
15390286 Interferon-gamma sensitizes osteosarcoma cells to Fas-induced apoptosis by up-regulating Fas receptors and caspase-8. no no
15540114 Sensitization of osteosarcoma cells to death receptor-mediated apoptosis by HDAC inhibitors through downregulation of cellular FLIP. no no
15912538 CTLA-4 is constitutively expressed on tumor cells and can trigger apoptosis upon ligand interaction. yes no
16213662 Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells. no no
16571651 Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells. no no
17493842 Caspase-8 dependent osteosarcoma cell apoptosis induced by proteasome inhibitor MG132. no no
17520676 Cyclin-dependent kinase inhibitor, flavopiridol, induces apoptosis and inhibits tumor growth in drug-resistant osteosarcoma and Ewing's family tumor cells. no no
18158779 Prognostic value of bax, cytochrome C, and caspase-8 protein expression in primary osteosarcoma. yes yes
18414033 Downregulation of c-jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model. no no
20678472 Sanguinarine induces apoptosis of human osteosarcoma cells through the extrinsic and intrinsic pathways. no no
21234653 Anti-tumor effects of dihydroartemisinin on human osteosarcoma. no no
21573491 Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. no no
21717192 Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2. no no
21964477 Okadaic acid induces apoptosis through the PKR, NF-?B and caspase pathway in human osteoblastic osteosarcoma MG63 cells. no no
22057483 RIP3 expression induces a death profile change in U2OS osteosarcoma cells after 5-ALA-PDT. no no
22126901 Tanshinone IIA induces apoptosis and inhibits the proliferation, migration, and invasion of the osteosarcoma MG-63 cell line in vitro. no no
22546756 Cyclooxygenase-2 inhibitors induce anoikis in osteosarcoma via PI3K/Akt pathway. no no
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