Results for RUNX2

General Information

Gene ID 860
Gene Symbol RUNX2
Gene Name runt-related transcription factor 2
Gene Type protein-coding
Cytoband 6p21
Ensembl ID ENSG00000124813
#miR regulators 5
Omim ID 119600 156510 600211
Gene ontology GO:0001503: ossification
GO:0001649: osteoblast differentiation
GO:0001958: endochondral ossification
GO:0002051: osteoblast fate commitment
GO:0002063: chondrocyte development
GO:0002076: osteoblast development
GO:0006367: transcription initiation from RNA polymerase II promoter
GO:0008284: positive regulation of cell proliferation
GO:0010467: gene expression
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0030217: T cell differentiation
GO:0030509: BMP signaling pathway
GO:0032332: positive regulation of chondrocyte differentiation
GO:0035115: embryonic forelimb morphogenesis
GO:0040036: regulation of fibroblast growth factor receptor signaling pathway
GO:0042475: odontogenesis of dentin-containing tooth
GO:0042487: regulation of odontogenesis of dentin-containing tooth
GO:0045669: positive regulation of osteoblast differentiation
GO:0045879: negative regulation of smoothened signaling pathway
GO:0048469: cell maturation
GO:0048701: embryonic cranial skeleton morphogenesis
GO:0048863: stem cell differentiation
GO:0071773: cellular response to BMP stimulus
GO:1901522: positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:0000790: nuclear chromatin
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005667: transcription factor complex
GO:0005515: protein binding
GO:0003682: chromatin binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0005524: ATP binding
GO:0044212: transcription regulatory region DNA binding
GO:0019904: protein domain specific binding
GO:0043425: bHLH transcription factor binding
GO:0070491: repressing transcription factor binding
KEGG pathways ---

PubMed abstracts associated with RUNX2

PMID Title Tumor Value
10569470 Expression of osteocalcin and its transcriptional regulators core-binding factor alpha 1 and MSX2 in osteoid-forming tumours. yes no
11545733 The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation. no no
12237108 Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB. no no
12393937 Basic fibroblast growth factor autocrine loop controls human osteosarcoma phenotyping and differentiation. no no
15516323 Effect of TNF-alpha on human osteosarcoma cell line Saos2--TNF-alpha regulation of bone sialoprotein gene expression in Saos2 osteoblast-like cells. no no
15583032 Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma. no no
15735172 An immunohistochemical analysis to evaluate an inverse correlation between Runx2/Cbfa1 and NF kappa B in human osteosarcoma. yes yes
15742288 Platelet-rich plasma enhances human osteoblast-like cell proliferation and differentiation. no no
16259979 Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB. no no
16354601 Immunohistochemical examination of cytological differentiation in osteosarcomas. yes no
16533764 Prostate-specific antigen modulates genes involved in bone remodeling and induces osteoblast differentiation of human osteosarcoma cell line SaOS-2. no no
17120184 Transient exposure to PTHrP (107-139) exerts anabolic effects through vascular endothelial growth factor receptor 2 in human osteoblastic cells in vitro. no no
17956871 Runx2- and histone deacetylase 3-mediated repression is relieved in differentiating human osteoblast cells to allow high bone sialoprotein expression. no no
18223689 Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis. no no
18567798 Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma. yes no
18838962 Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects. no no
18931939 Elevated expression of Runx2 as a key parameter in the etiology of osteosarcoma. no no
19688969 Prognostic implication of immunohistochemical Runx2 expression in osteosarcoma. yes yes
19746447 Runx2-mediated bcl-2 gene expression contributes to nitric oxide protection against hydrogen peroxide-induced osteoblast apoptosis. no no
19894220 Proteasome inhibition with bortezomib suppresses growth and induces apoptosis in osteosarcoma. no no
20053387 RUNX2 regulates the effects of TNFalpha on proliferation and apoptosis in SaOs-2 cells. no no
20465837 Expression analysis of genes associated with human osteosarcoma tumors shows correlation of RUNX2 overexpression with poor response to chemotherapy. yes yes
20530675 Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression. yes no
20627196 Epidermal growth factor and bone morphogenetic proteins upregulate osteoblast proliferation and osteoblastic markers and inhibit bone nodule formation. no no
21178508 BMP-2 inhibits the tumorigenicity of cancer stem cells in human osteosarcoma OS99-1 cell line. no no
21951664 RUNX2 expression in developing human bones and various bone tumors. yes no
22158627 Genomic promoter occupancy of runt-related transcription factor RUNX2 in Osteosarcoma cells identifies genes involved in cell adhesion and motility. no no
22949168 The cancer-related transcription factor Runx2 modulates cell proliferation in human osteosarcoma cell lines. no no
23137772 A genome-wide approach to comparative oncology: high-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations. yes no
23144859 Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma. yes no
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