General Information
Gene ID | 8626 |
---|---|
Gene Symbol | TP63 |
Gene Name | tumor protein p63 |
Gene Type | protein-coding |
Cytoband | 3q28 |
Ensembl ID | ENSG00000073282 |
#miR regulators | 21 |
Omim ID | 103285 106260 129400 603273 603543 604292 605289 |
Gene ontology |
GO:0000122: negative regulation of transcription from RNA polymerase II promoter GO:0001501: skeletal system development GO:0001736: establishment of planar polarity GO:0002053: positive regulation of mesenchymal cell proliferation GO:0002064: epithelial cell development GO:0006338: chromatin remodeling GO:0006978: DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0007219: Notch signaling pathway GO:0007499: ectoderm and mesoderm interaction GO:0007569: cell aging GO:0043066: negative regulation of apoptotic process GO:0009954: proximal/distal pattern formation GO:0010165: response to X-ray GO:0010259: multicellular organismal aging GO:0010332: response to gamma radiation GO:0010481: epidermal cell division GO:0045893: positive regulation of transcription, DNA-dependent GO:0045892: negative regulation of transcription, DNA-dependent GO:0030216: keratinocyte differentiation GO:0030326: embryonic limb morphogenesis GO:0030859: polarized epithelial cell differentiation GO:0031069: hair follicle morphogenesis GO:0031571: mitotic G1 DNA damage checkpoint GO:0034644: cellular response to UV GO:0036342: post-anal tail morphogenesis GO:0042475: odontogenesis of dentin-containing tooth GO:0042771: intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0043523: regulation of neuron apoptotic process GO:0043616: keratinocyte proliferation GO:0045617: negative regulation of keratinocyte differentiation GO:0045669: positive regulation of osteoblast differentiation GO:0045747: positive regulation of Notch signaling pathway GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0048485: sympathetic nervous system development GO:0048745: smooth muscle tissue development GO:0048807: female genitalia morphogenesis GO:0051289: protein homotetramerization GO:0051402: neuron apoptotic process GO:0060157: urinary bladder development GO:0060197: cloacal septation GO:0060513: prostatic bud formation GO:0060529: squamous basal epithelial stem cell differentiation involved in prostate gland acinus development GO:2000271: positive regulation of fibroblast apoptotic process GO:2000381: negative regulation of mesoderm development GO:0000785: chromatin GO:0000790: nuclear chromatin GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0005654: nucleoplasm GO:0005667: transcription factor complex GO:0005794: Golgi apparatus GO:0030425: dendrite GO:0005515: protein binding GO:0001077: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0002039: p53 binding GO:0003677: DNA binding GO:0003682: chromatin binding GO:0003684: damaged DNA binding GO:0003690: double-stranded DNA binding GO:0003700: sequence-specific DNA binding transcription factor activity GO:0046872: metal ion binding GO:0042802: identical protein binding GO:0044212: transcription regulatory region DNA binding GO:0043565: sequence-specific DNA binding |
KEGG pathways | --- |
PMID | Title | Tumor | Value |
---|---|---|---|
15237589 | Low expression of p63 and p73 in osteosarcoma. | yes | no |
17568187 | Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines. | no | no |
21631272 | p63 expression in giant cell-containing lesions of bone and soft tissue. | yes | yes |
22623071 | Nuclear p63 expression in osteoblastic tumors. | yes | yes |
title | all | all |