Results for TP63

General Information

Gene ID 8626
Gene Symbol TP63
Gene Name tumor protein p63
Gene Type protein-coding
Cytoband 3q28
Ensembl ID ENSG00000073282
#miR regulators 21
Omim ID 103285 106260 129400 603273 603543 604292 605289
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0001501: skeletal system development
GO:0001736: establishment of planar polarity
GO:0002053: positive regulation of mesenchymal cell proliferation
GO:0002064: epithelial cell development
GO:0006338: chromatin remodeling
GO:0006978: DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007219: Notch signaling pathway
GO:0007499: ectoderm and mesoderm interaction
GO:0007569: cell aging
GO:0043066: negative regulation of apoptotic process
GO:0009954: proximal/distal pattern formation
GO:0010165: response to X-ray
GO:0010259: multicellular organismal aging
GO:0010332: response to gamma radiation
GO:0010481: epidermal cell division
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0030216: keratinocyte differentiation
GO:0030326: embryonic limb morphogenesis
GO:0030859: polarized epithelial cell differentiation
GO:0031069: hair follicle morphogenesis
GO:0031571: mitotic G1 DNA damage checkpoint
GO:0034644: cellular response to UV
GO:0036342: post-anal tail morphogenesis
GO:0042475: odontogenesis of dentin-containing tooth
GO:0042771: intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043523: regulation of neuron apoptotic process
GO:0043616: keratinocyte proliferation
GO:0045617: negative regulation of keratinocyte differentiation
GO:0045669: positive regulation of osteoblast differentiation
GO:0045747: positive regulation of Notch signaling pathway
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048485: sympathetic nervous system development
GO:0048745: smooth muscle tissue development
GO:0048807: female genitalia morphogenesis
GO:0051289: protein homotetramerization
GO:0051402: neuron apoptotic process
GO:0060157: urinary bladder development
GO:0060197: cloacal septation
GO:0060513: prostatic bud formation
GO:0060529: squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:2000271: positive regulation of fibroblast apoptotic process
GO:2000381: negative regulation of mesoderm development
GO:0000785: chromatin
GO:0000790: nuclear chromatin
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005667: transcription factor complex
GO:0005794: Golgi apparatus
GO:0030425: dendrite
GO:0005515: protein binding
GO:0001077: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0002039: p53 binding
GO:0003677: DNA binding
GO:0003682: chromatin binding
GO:0003684: damaged DNA binding
GO:0003690: double-stranded DNA binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0046872: metal ion binding
GO:0042802: identical protein binding
GO:0044212: transcription regulatory region DNA binding
GO:0043565: sequence-specific DNA binding
KEGG pathways ---

PubMed abstracts associated with TP63

PMID Title Tumor Value
15237589 Low expression of p63 and p73 in osteosarcoma. yes no
17568187 Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines. no no
21631272 p63 expression in giant cell-containing lesions of bone and soft tissue. yes yes
22623071 Nuclear p63 expression in osteoblastic tumors. yes yes
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