Results for TNFSF10

General Information

Gene ID 8743
Gene Symbol TNFSF10
Gene Name tumor necrosis factor (ligand) superfamily, member 10
Gene Type protein-coding
Cytoband 3q26
Ensembl ID ENSG00000121858
#miR regulators 17
Omim ID 603598
Gene ontology GO:0006915: apoptotic process
GO:0007165: signal transduction
GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006955: immune response
GO:0007267: cell-cell signaling
GO:0043065: positive regulation of apoptotic process
GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043280: positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0090200: positive regulation of release of cytochrome c from mitochondria
GO:0097190: apoptotic signaling pathway
GO:2001238: positive regulation of extrinsic apoptotic signaling pathway
GO:2001239: regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0005576: extracellular region
GO:0005887: integral to plasma membrane
GO:0005615: extracellular space
GO:0005515: protein binding
GO:0005102: receptor binding
GO:0005125: cytokine activity
GO:0005164: tumor necrosis factor receptor binding
GO:0046872: metal ion binding
KEGG pathways 4060: Cytokine-cytokine receptor interaction
4210: Apoptosis
4650: Natural killer cell mediated cytotoxicity

PubMed abstracts associated with TNFSF10

PMID Title Tumor Value
11992538 Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to Apo2L/TRAIL-induced apoptosis. no no
12838325 Progressive resistance of BTK-143 osteosarcoma cells to Apo2L/TRAIL-induced apoptosis is mediated by acquisition of DcR2/TRAIL-R4 expression: resensitisation with chemotherapy. no no
12919886 Chemotherapeutic agents sensitize sarcoma cell lines to tumor necrosis factor-related apoptosis-inducing ligand-induced caspase-8 activation, apoptosis and loss of mitochondrial membrane potential. no no
15547696 Sensitization of multidrug resistant human ostesarcoma cells to Apo2 Ligand/TRAIL-induced apoptosis by inhibition of the Akt/PKB kinase. no no
16571651 Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells. no no
17465200 LKB1 is crucial for TRAIL-mediated apoptosis induction in osteosarcoma. no no
20041491 Ionizing radiation enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulations of death receptor 4 (DR4) and death receptor 5 (DR5) in human osteosarcoma cells. no no
21297379 Bisphosphonate enhances TRAIL sensitivity to human osteosarcoma cells via death receptor 5 upregulation. no no
22147650 Prion proteins (PRNP and PRND) are over-expressed in osteosarcoma. yes no
22354724 Potent growth-inhibitory effect of TRAIL therapy mediated by double-regulated oncolytic adenovirus on osteosarcoma. no no
23145797 Ether à go-go 1 silencing in combination with TRAIL overexpression has synergistic antitumor effects on osteosarcoma. no no
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