General Information
Gene ID | 8772 |
---|---|
Gene Symbol | FADD |
Gene Name | Fas (TNFRSF6)-associated via death domain |
Gene Type | protein-coding |
Cytoband | 11q13.3 |
Ensembl ID | ENSG00000168040 |
#miR regulators | 5 |
Omim ID | 602457 613759 |
Gene ontology |
GO:0002224: toll-like receptor signaling pathway GO:0002756: MyD88-independent toll-like receptor signaling pathway GO:0006915: apoptotic process GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0070265: necrotic cell death GO:0008625: extrinsic apoptotic signaling pathway via death domain receptors GO:0019048: modulation by virus of host morphology or physiology GO:0071260: cellular response to mechanical stimulus GO:0032757: positive regulation of interleukin-8 production GO:0032760: positive regulation of tumor necrosis factor production GO:0034138: toll-like receptor 3 signaling pathway GO:0034142: toll-like receptor 4 signaling pathway GO:0035666: TRIF-dependent toll-like receptor signaling pathway GO:0043065: positive regulation of apoptotic process GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0045087: innate immune response GO:0045862: positive regulation of proteolysis GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0051291: protein heterooligomerization GO:0051607: defense response to virus GO:0060340: positive regulation of type I interferon-mediated signaling pathway GO:0097190: apoptotic signaling pathway GO:0097191: extrinsic apoptotic signaling pathway GO:0097202: activation of cysteine-type endopeptidase activity GO:2001238: positive regulation of extrinsic apoptotic signaling pathway GO:2001239: regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:0005829: cytosol GO:0043005: neuron projection GO:0031264: death-inducing signaling complex GO:0031265: CD95 death-inducing signaling complex GO:0044297: cell body GO:0045121: membrane raft GO:0005515: protein binding GO:0002020: protease binding GO:0005123: death receptor binding GO:0005164: tumor necrosis factor receptor binding GO:0042802: identical protein binding GO:0032813: tumor necrosis factor receptor superfamily binding |
KEGG pathways |
4210: Apoptosis 4620: Toll-like receptor signaling pathway 4622: RIG-I-like receptor signaling pathway 5010: Alzheimer's disease 5142: Chagas disease (American trypanosomiasis) 5200: Pathways in cancer |
PMID | Title | Tumor | Value |
---|---|---|---|
11093825 | Cisplatin (CDDP) sensitizes human osteosarcoma cell to Fas/CD95-mediated apoptosis by down-regulating FLIP-L expression. | no | no |
14647441 | FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells. | no | no |
21287529 | Effect of the histone deacetylase inhibitor SNDX-275 on Fas signaling in osteosarcoma cells and the feasibility of its topical application for the treatment of osteosarcoma lung metastases. | no | no |
title | all | all |