Results for FADD

General Information

Gene ID 8772
Gene Symbol FADD
Gene Name Fas (TNFRSF6)-associated via death domain
Gene Type protein-coding
Cytoband 11q13.3
Ensembl ID ENSG00000168040
#miR regulators 5
Omim ID 602457 613759
Gene ontology GO:0002224: toll-like receptor signaling pathway
GO:0002756: MyD88-independent toll-like receptor signaling pathway
GO:0006915: apoptotic process
GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0070265: necrotic cell death
GO:0008625: extrinsic apoptotic signaling pathway via death domain receptors
GO:0019048: modulation by virus of host morphology or physiology
GO:0071260: cellular response to mechanical stimulus
GO:0032757: positive regulation of interleukin-8 production
GO:0032760: positive regulation of tumor necrosis factor production
GO:0034138: toll-like receptor 3 signaling pathway
GO:0034142: toll-like receptor 4 signaling pathway
GO:0035666: TRIF-dependent toll-like receptor signaling pathway
GO:0043065: positive regulation of apoptotic process
GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0045087: innate immune response
GO:0045862: positive regulation of proteolysis
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0051291: protein heterooligomerization
GO:0051607: defense response to virus
GO:0060340: positive regulation of type I interferon-mediated signaling pathway
GO:0097190: apoptotic signaling pathway
GO:0097191: extrinsic apoptotic signaling pathway
GO:0097202: activation of cysteine-type endopeptidase activity
GO:2001238: positive regulation of extrinsic apoptotic signaling pathway
GO:2001239: regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0005829: cytosol
GO:0043005: neuron projection
GO:0031264: death-inducing signaling complex
GO:0031265: CD95 death-inducing signaling complex
GO:0044297: cell body
GO:0045121: membrane raft
GO:0005515: protein binding
GO:0002020: protease binding
GO:0005123: death receptor binding
GO:0005164: tumor necrosis factor receptor binding
GO:0042802: identical protein binding
GO:0032813: tumor necrosis factor receptor superfamily binding
KEGG pathways 4210: Apoptosis
4620: Toll-like receptor signaling pathway
4622: RIG-I-like receptor signaling pathway
5010: Alzheimer's disease
5142: Chagas disease (American trypanosomiasis)
5200: Pathways in cancer

PubMed abstracts associated with FADD

PMID Title Tumor Value
11093825 Cisplatin (CDDP) sensitizes human osteosarcoma cell to Fas/CD95-mediated apoptosis by down-regulating FLIP-L expression. no no
14647441 FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells. no no
21287529 Effect of the histone deacetylase inhibitor SNDX-275 on Fas signaling in osteosarcoma cells and the feasibility of its topical application for the treatment of osteosarcoma lung metastases. no no
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