Results for TNFRSF11A

General Information

Gene ID 8792
Gene Symbol TNFRSF11A
Gene Name tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Gene Type protein-coding
Cytoband 18q22.1
Ensembl ID ENSG00000141655
#miR regulators 1
Omim ID 174810 602080 603499 612301
Gene ontology GO:0001503: ossification
GO:0002250: adaptive immune response
GO:0002548: monocyte chemotaxis
GO:0007165: signal transduction
GO:0007267: cell-cell signaling
GO:0048535: lymph node development
GO:0008284: positive regulation of cell proliferation
GO:0009314: response to radiation
GO:0030316: osteoclast differentiation
GO:0032496: response to lipopolysaccharide
GO:0033209: tumor necrosis factor-mediated signaling pathway
GO:0034097: response to cytokine stimulus
GO:0034612: response to tumor necrosis factor
GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043507: positive regulation of JUN kinase activity
GO:0051091: positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092: positive regulation of NF-kappaB transcription factor activity
GO:0060086: circadian temperature homeostasis
GO:0060749: mammary gland alveolus development
GO:0070555: response to interleukin-1
GO:0071812: positive regulation of fever generation by positive regulation of prostaglandin secretion
GO:0071847: TNFSF11-mediated signaling pathway
GO:0071848: positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
GO:0016021: integral to membrane
GO:0009897: external side of plasma membrane
GO:0005515: protein binding
GO:0004872: receptor activity
GO:0004888: transmembrane signaling receptor activity
GO:0005031: tumor necrosis factor-activated receptor activity
GO:0046872: metal ion binding
GO:0019955: cytokine binding
KEGG pathways 4060: Cytokine-cytokine receptor interaction
4380: Osteoclast differentiation
5323: Rheumatoid arthritis

PubMed abstracts associated with TNFRSF11A

PMID Title Tumor Value
11351498 Mutation screening of the TNFRSF11A gene encoding receptor activator of NF kappa B (RANK) in familial and sporadic Paget's disease of bone and osteosarcoma. yes no
12673693 Determination of a minimal region of loss of heterozygosity on chromosome 18q21.33 in osteosarcoma. yes no
17323424 Human osteosarcoma cells express functional receptor activator of nuclear factor-kappa B. no no
17982618 Receptor activator of nuclear factor-kappaB ligand (RANKL) directly modulates the gene expression profile of RANK-positive Saos-2 human osteosarcoma cells. no no
20955951 Markers of bone remodeling in neoplastic and bone-related lesions. yes no
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