Results for TNFRSF10B

General Information

Gene ID 8795
Gene Symbol TNFRSF10B
Gene Name tumor necrosis factor receptor superfamily, member 10b
Gene Type protein-coding
Cytoband 8p22-p21
Ensembl ID ENSG00000120889
#miR regulators 15
Omim ID 275355 603612
Gene ontology GO:0006915: apoptotic process
GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007166: cell surface receptor signaling pathway
GO:0007250: activation of NF-kappaB-inducing kinase activity
GO:0008625: extrinsic apoptotic signaling pathway via death domain receptors
GO:0042981: regulation of apoptotic process
GO:0071260: cellular response to mechanical stimulus
GO:0034976: response to endoplasmic reticulum stress
GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0070059: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0097190: apoptotic signaling pathway
GO:2001239: regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0005886: plasma membrane
GO:0016021: integral to membrane
GO:0005515: protein binding
GO:0004872: receptor activity
GO:0045569: TRAIL binding
KEGG pathways 4060: Cytokine-cytokine receptor interaction
4115: p53 signaling pathway
4210: Apoptosis
4650: Natural killer cell mediated cytotoxicity

PubMed abstracts associated with TNFRSF10B

PMID Title Tumor Value
11992538 Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to Apo2L/TRAIL-induced apoptosis. no no
12838325 Progressive resistance of BTK-143 osteosarcoma cells to Apo2L/TRAIL-induced apoptosis is mediated by acquisition of DcR2/TRAIL-R4 expression: resensitisation with chemotherapy. no no
12919886 Chemotherapeutic agents sensitize sarcoma cell lines to tumor necrosis factor-related apoptosis-inducing ligand-induced caspase-8 activation, apoptosis and loss of mitochondrial membrane potential. no no
15547696 Sensitization of multidrug resistant human ostesarcoma cells to Apo2 Ligand/TRAIL-induced apoptosis by inhibition of the Akt/PKB kinase. no no
16327988 Anticancer agents sensitize osteosarcoma cells to TNF-related apoptosis-inducing ligand downmodulating IAP family proteins. no no
16571651 Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells. no no
20041491 Ionizing radiation enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulations of death receptor 4 (DR4) and death receptor 5 (DR5) in human osteosarcoma cells. no no
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