General Information
Gene ID | 8795 |
---|---|
Gene Symbol | TNFRSF10B |
Gene Name | tumor necrosis factor receptor superfamily, member 10b |
Gene Type | protein-coding |
Cytoband | 8p22-p21 |
Ensembl ID | ENSG00000120889 |
#miR regulators | 15 |
Omim ID | 275355 603612 |
Gene ontology |
GO:0006915: apoptotic process GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0007166: cell surface receptor signaling pathway GO:0007250: activation of NF-kappaB-inducing kinase activity GO:0008625: extrinsic apoptotic signaling pathway via death domain receptors GO:0042981: regulation of apoptotic process GO:0071260: cellular response to mechanical stimulus GO:0034976: response to endoplasmic reticulum stress GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0070059: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0097190: apoptotic signaling pathway GO:2001239: regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:0005886: plasma membrane GO:0016021: integral to membrane GO:0005515: protein binding GO:0004872: receptor activity GO:0045569: TRAIL binding |
KEGG pathways |
4060: Cytokine-cytokine receptor interaction 4115: p53 signaling pathway 4210: Apoptosis 4650: Natural killer cell mediated cytotoxicity |
PMID | Title | Tumor | Value |
---|---|---|---|
11992538 | Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to Apo2L/TRAIL-induced apoptosis. | no | no |
12838325 | Progressive resistance of BTK-143 osteosarcoma cells to Apo2L/TRAIL-induced apoptosis is mediated by acquisition of DcR2/TRAIL-R4 expression: resensitisation with chemotherapy. | no | no |
12919886 | Chemotherapeutic agents sensitize sarcoma cell lines to tumor necrosis factor-related apoptosis-inducing ligand-induced caspase-8 activation, apoptosis and loss of mitochondrial membrane potential. | no | no |
15547696 | Sensitization of multidrug resistant human ostesarcoma cells to Apo2 Ligand/TRAIL-induced apoptosis by inhibition of the Akt/PKB kinase. | no | no |
16327988 | Anticancer agents sensitize osteosarcoma cells to TNF-related apoptosis-inducing ligand downmodulating IAP family proteins. | no | no |
16571651 | Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells. | no | no |
20041491 | Ionizing radiation enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulations of death receptor 4 (DR4) and death receptor 5 (DR5) in human osteosarcoma cells. | no | no |
title | all | all |