Results for TNFRSF10A

General Information

Gene ID 8797
Gene Symbol TNFRSF10A
Gene Name tumor necrosis factor receptor superfamily, member 10a
Gene Type protein-coding
Cytoband 8p21
Ensembl ID ENSG00000104689
#miR regulators 3
Omim ID 603611
Gene ontology GO:0007165: signal transduction
GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007250: activation of NF-kappaB-inducing kinase activity
GO:0008625: extrinsic apoptotic signaling pathway via death domain receptors
GO:0071260: cellular response to mechanical stimulus
GO:0097191: extrinsic apoptotic signaling pathway
GO:0016021: integral to membrane
GO:0005515: protein binding
GO:0004872: receptor activity
GO:0005035: death receptor activity
GO:0008134: transcription factor binding
GO:0045569: TRAIL binding
KEGG pathways 4060: Cytokine-cytokine receptor interaction
4210: Apoptosis
4650: Natural killer cell mediated cytotoxicity

PubMed abstracts associated with TNFRSF10A

PMID Title Tumor Value
11992538 Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to Apo2L/TRAIL-induced apoptosis. no no
12838325 Progressive resistance of BTK-143 osteosarcoma cells to Apo2L/TRAIL-induced apoptosis is mediated by acquisition of DcR2/TRAIL-R4 expression: resensitisation with chemotherapy. no no
12919886 Chemotherapeutic agents sensitize sarcoma cell lines to tumor necrosis factor-related apoptosis-inducing ligand-induced caspase-8 activation, apoptosis and loss of mitochondrial membrane potential. no no
14999771 Mutation analysis of the apoptotic \death-receptors\ and the adaptors TRADD and FADD/MORT-1 in osteosarcoma tumor samples and osteosarcoma cell lines. yes no
15547696 Sensitization of multidrug resistant human ostesarcoma cells to Apo2 Ligand/TRAIL-induced apoptosis by inhibition of the Akt/PKB kinase. no no
20041491 Ionizing radiation enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulations of death receptor 4 (DR4) and death receptor 5 (DR5) in human osteosarcoma cells. no no
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