General Information
| Gene ID | 8797 |
|---|---|
| Gene Symbol | TNFRSF10A |
| Gene Name | tumor necrosis factor receptor superfamily, member 10a |
| Gene Type | protein-coding |
| Cytoband | 8p21 |
| Ensembl ID | ENSG00000104689 |
| #miR regulators | 3 |
| Omim ID | 603611 |
| Gene ontology |
GO:0007165: signal transduction GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0007250: activation of NF-kappaB-inducing kinase activity GO:0008625: extrinsic apoptotic signaling pathway via death domain receptors GO:0071260: cellular response to mechanical stimulus GO:0097191: extrinsic apoptotic signaling pathway GO:0016021: integral to membrane GO:0005515: protein binding GO:0004872: receptor activity GO:0005035: death receptor activity GO:0008134: transcription factor binding GO:0045569: TRAIL binding |
| KEGG pathways |
4060: Cytokine-cytokine receptor interaction 4210: Apoptosis 4650: Natural killer cell mediated cytotoxicity |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 11992538 | Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to Apo2L/TRAIL-induced apoptosis. | no | no |
| 12838325 | Progressive resistance of BTK-143 osteosarcoma cells to Apo2L/TRAIL-induced apoptosis is mediated by acquisition of DcR2/TRAIL-R4 expression: resensitisation with chemotherapy. | no | no |
| 12919886 | Chemotherapeutic agents sensitize sarcoma cell lines to tumor necrosis factor-related apoptosis-inducing ligand-induced caspase-8 activation, apoptosis and loss of mitochondrial membrane potential. | no | no |
| 14999771 | Mutation analysis of the apoptotic \death-receptors\ and the adaptors TRADD and FADD/MORT-1 in osteosarcoma tumor samples and osteosarcoma cell lines. | yes | no |
| 15547696 | Sensitization of multidrug resistant human ostesarcoma cells to Apo2 Ligand/TRAIL-induced apoptosis by inhibition of the Akt/PKB kinase. | no | no |
| 20041491 | Ionizing radiation enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulations of death receptor 4 (DR4) and death receptor 5 (DR5) in human osteosarcoma cells. | no | no |
| title | all | all |