Results for CFLAR

General Information

Gene ID 8837
Gene Symbol CFLAR
Gene Name CASP8 and FADD-like apoptosis regulator
Gene Type protein-coding
Cytoband 2q33-q34
Ensembl ID ENSG00000003402
#miR regulators 17
Omim ID 603599
Gene ontology GO:0006915: apoptotic process
GO:0006508: proteolysis
GO:0007519: skeletal muscle tissue development
GO:0043066: negative regulation of apoptotic process
GO:0014732: skeletal muscle atrophy
GO:0014842: regulation of satellite cell proliferation
GO:0014866: skeletal myofibril assembly
GO:0019048: modulation by virus of host morphology or physiology
GO:0043085: positive regulation of catalytic activity
GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043403: skeletal muscle tissue regeneration
GO:0051092: positive regulation of NF-kappaB transcription factor activity
GO:0097190: apoptotic signaling pathway
GO:1901740: negative regulation of myoblast fusion
GO:1902042: negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001237: negative regulation of extrinsic apoptotic signaling pathway
GO:2001239: regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0005829: cytosol
GO:0005737: cytoplasm
GO:0031264: death-inducing signaling complex
GO:0005515: protein binding
GO:0004197: cysteine-type endopeptidase activity
GO:0002020: protease binding
GO:0008047: enzyme activator activity
KEGG pathways 4210: Apoptosis
5142: Chagas disease (American trypanosomiasis)

PubMed abstracts associated with CFLAR

PMID Title Tumor Value
11093825 Cisplatin (CDDP) sensitizes human osteosarcoma cell to Fas/CD95-mediated apoptosis by down-regulating FLIP-L expression. no no
11992538 Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to Apo2L/TRAIL-induced apoptosis. no no
12919886 Chemotherapeutic agents sensitize sarcoma cell lines to tumor necrosis factor-related apoptosis-inducing ligand-induced caspase-8 activation, apoptosis and loss of mitochondrial membrane potential. no no
14647441 FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells. no no
15540114 Sensitization of osteosarcoma cells to death receptor-mediated apoptosis by HDAC inhibitors through downregulation of cellular FLIP. no no
19160414 Identification and expansion of human osteosarcoma-cancer-stem cells by long-term 3-aminobenzamide treatment. no no
20041491 Ionizing radiation enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulations of death receptor 4 (DR4) and death receptor 5 (DR5) in human osteosarcoma cells. no no
23255321 Expression of c-FLIP in pulmonary metastases in osteosarcoma patients and human xenografts. yes no
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