General Information
Gene ID | 8837 |
---|---|
Gene Symbol | CFLAR |
Gene Name | CASP8 and FADD-like apoptosis regulator |
Gene Type | protein-coding |
Cytoband | 2q33-q34 |
Ensembl ID | ENSG00000003402 |
#miR regulators | 17 |
Omim ID | 603599 |
Gene ontology |
GO:0006915: apoptotic process GO:0006508: proteolysis GO:0007519: skeletal muscle tissue development GO:0043066: negative regulation of apoptotic process GO:0014732: skeletal muscle atrophy GO:0014842: regulation of satellite cell proliferation GO:0014866: skeletal myofibril assembly GO:0019048: modulation by virus of host morphology or physiology GO:0043085: positive regulation of catalytic activity GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043403: skeletal muscle tissue regeneration GO:0051092: positive regulation of NF-kappaB transcription factor activity GO:0097190: apoptotic signaling pathway GO:1901740: negative regulation of myoblast fusion GO:1902042: negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:2001237: negative regulation of extrinsic apoptotic signaling pathway GO:2001239: regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:0005829: cytosol GO:0005737: cytoplasm GO:0031264: death-inducing signaling complex GO:0005515: protein binding GO:0004197: cysteine-type endopeptidase activity GO:0002020: protease binding GO:0008047: enzyme activator activity |
KEGG pathways |
4210: Apoptosis 5142: Chagas disease (American trypanosomiasis) |
PMID | Title | Tumor | Value |
---|---|---|---|
11093825 | Cisplatin (CDDP) sensitizes human osteosarcoma cell to Fas/CD95-mediated apoptosis by down-regulating FLIP-L expression. | no | no |
11992538 | Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to Apo2L/TRAIL-induced apoptosis. | no | no |
12919886 | Chemotherapeutic agents sensitize sarcoma cell lines to tumor necrosis factor-related apoptosis-inducing ligand-induced caspase-8 activation, apoptosis and loss of mitochondrial membrane potential. | no | no |
14647441 | FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells. | no | no |
15540114 | Sensitization of osteosarcoma cells to death receptor-mediated apoptosis by HDAC inhibitors through downregulation of cellular FLIP. | no | no |
19160414 | Identification and expansion of human osteosarcoma-cancer-stem cells by long-term 3-aminobenzamide treatment. | no | no |
20041491 | Ionizing radiation enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulations of death receptor 4 (DR4) and death receptor 5 (DR5) in human osteosarcoma cells. | no | no |
23255321 | Expression of c-FLIP in pulmonary metastases in osteosarcoma patients and human xenografts. | yes | no |
title | all | all |