General Information
Gene ID | 8877 |
---|---|
Gene Symbol | SPHK1 |
Gene Name | sphingosine kinase 1 |
Gene Type | protein-coding |
Cytoband | 17q25.2 |
Ensembl ID | ENSG00000176170 |
#miR regulators | 1 |
Omim ID | 603730 |
Gene ontology |
GO:0001568: blood vessel development GO:0006457: protein folding GO:0007165: signal transduction GO:0035556: intracellular signal transduction GO:0006665: sphingolipid metabolic process GO:0006670: sphingosine metabolic process GO:0006954: inflammatory response GO:0007205: protein kinase C-activating G-protein coupled receptor signaling pathway GO:0019722: calcium-mediated signaling GO:0007420: brain development GO:0043066: negative regulation of apoptotic process GO:0045987: positive regulation of smooth muscle contraction GO:0010803: regulation of tumor necrosis factor-mediated signaling pathway GO:0030148: sphingolipid biosynthetic process GO:0030307: positive regulation of cell growth GO:0030335: positive regulation of cell migration GO:0031398: positive regulation of protein ubiquitination GO:0032651: regulation of interleukin-1 beta production GO:0042346: positive regulation of NF-kappaB import into nucleus GO:0044267: cellular protein metabolic process GO:0044281: small molecule metabolic process GO:0045766: positive regulation of angiogenesis GO:0045931: positive regulation of mitotic cell cycle GO:0046521: sphingoid catabolic process GO:0048146: positive regulation of fibroblast proliferation GO:0051084: 'de novo' posttranslational protein folding GO:0051092: positive regulation of NF-kappaB transcription factor activity GO:0005886: plasma membrane GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0005515: protein binding GO:0000287: magnesium ion binding GO:0003677: DNA binding GO:0004143: diacylglycerol kinase activity GO:0005516: calmodulin binding GO:0005524: ATP binding GO:0008481: sphinganine kinase activity GO:0017050: D-erythro-sphingosine kinase activity GO:0051721: protein phosphatase 2A binding |
KEGG pathways |
600: Sphingolipid metabolism 1100: Metabolic pathways 4020: Calcium signaling pathway 4370: VEGF signaling pathway 4666: Fc gamma R-mediated phagocytosis |
PMID | Title | Tumor | Value |
---|---|---|---|
22583777 | Co-administration phenoxodiol with doxorubicin synergistically inhibit the activity of sphingosine kinase-1 (SphK1), a potential oncogene of osteosarcoma, to suppress osteosarcoma cell growth both in vivo and in vitro. | yes | no |
title | all | all |