Results for SPHK1

General Information

Gene ID 8877
Gene Symbol SPHK1
Gene Name sphingosine kinase 1
Gene Type protein-coding
Cytoband 17q25.2
Ensembl ID ENSG00000176170
#miR regulators 1
Omim ID 603730
Gene ontology GO:0001568: blood vessel development
GO:0006457: protein folding
GO:0007165: signal transduction
GO:0035556: intracellular signal transduction
GO:0006665: sphingolipid metabolic process
GO:0006670: sphingosine metabolic process
GO:0006954: inflammatory response
GO:0007205: protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0019722: calcium-mediated signaling
GO:0007420: brain development
GO:0043066: negative regulation of apoptotic process
GO:0045987: positive regulation of smooth muscle contraction
GO:0010803: regulation of tumor necrosis factor-mediated signaling pathway
GO:0030148: sphingolipid biosynthetic process
GO:0030307: positive regulation of cell growth
GO:0030335: positive regulation of cell migration
GO:0031398: positive regulation of protein ubiquitination
GO:0032651: regulation of interleukin-1 beta production
GO:0042346: positive regulation of NF-kappaB import into nucleus
GO:0044267: cellular protein metabolic process
GO:0044281: small molecule metabolic process
GO:0045766: positive regulation of angiogenesis
GO:0045931: positive regulation of mitotic cell cycle
GO:0046521: sphingoid catabolic process
GO:0048146: positive regulation of fibroblast proliferation
GO:0051084: 'de novo' posttranslational protein folding
GO:0051092: positive regulation of NF-kappaB transcription factor activity
GO:0005886: plasma membrane
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005515: protein binding
GO:0000287: magnesium ion binding
GO:0003677: DNA binding
GO:0004143: diacylglycerol kinase activity
GO:0005516: calmodulin binding
GO:0005524: ATP binding
GO:0008481: sphinganine kinase activity
GO:0017050: D-erythro-sphingosine kinase activity
GO:0051721: protein phosphatase 2A binding
KEGG pathways 600: Sphingolipid metabolism
1100: Metabolic pathways
4020: Calcium signaling pathway
4370: VEGF signaling pathway
4666: Fc gamma R-mediated phagocytosis

PubMed abstracts associated with SPHK1

PMID Title Tumor Value
22583777 Co-administration phenoxodiol with doxorubicin synergistically inhibit the activity of sphingosine kinase-1 (SphK1), a potential oncogene of osteosarcoma, to suppress osteosarcoma cell growth both in vivo and in vitro. yes no
title all all