Results for CCNE1

General Information

Gene ID 898
Gene Symbol CCNE1
Gene Name cyclin E1
Gene Type protein-coding
Cytoband 19q12
Ensembl ID ENSG00000105173
#miR regulators 10
Omim ID 123837
Gene ontology GO:0000079: regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082: G1/S transition of mitotic cell cycle
GO:0000083: regulation of transcription involved in G1/S phase of mitotic cell cycle
GO:0000278: mitotic cell cycle
GO:0016055: Wnt receptor signaling pathway
GO:0006270: DNA replication initiation
GO:0006468: protein phosphorylation
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0030521: androgen receptor signaling pathway
GO:0051301: cell division
GO:0000307: cyclin-dependent protein kinase holoenzyme complex
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005654: nucleoplasm
GO:0005515: protein binding
GO:0003713: transcription coactivator activity
GO:0016301: kinase activity
GO:0016538: cyclin-dependent protein serine/threonine kinase regulator activity
GO:0019901: protein kinase binding
GO:0050681: androgen receptor binding
KEGG pathways 4110: Cell cycle
4114: Oocyte meiosis
4115: p53 signaling pathway
5200: Pathways in cancer
5215: Prostate cancer
5222: Small cell lung cancer

PubMed abstracts associated with CCNE1

PMID Title Tumor Value
1388095 Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. no no
9154817 Glucocorticoid receptor-mediated cell cycle arrest is achieved through distinct cell-specific transcriptional regulatory mechanisms. no no
9538120 Prognostic significance of cyclin expression in human osteosarcoma. yes yes
10339667 Expression of G1 phase regulators in MG-63 osteosarcoma cell line. no no
11707342 Identification of twenty-two candidate markers for human osteogenic sarcoma. no no
12368234 Gamma-tocopherol inhibits human cancer cell cycle progression and cell proliferation by down-regulation of cyclins. no no
12907249 Inhibition of MG-63 cell cycle progression by synthetic vitamin D3 analogs mediated by p27, Cdk2, cyclin E, and the retinoblastoma protein. no no
17569615 IFI16 inhibits tumorigenicity and cell proliferation of bone and cartilage tumor cells. no no
19455146 Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation. no no
20053387 RUNX2 regulates the effects of TNFalpha on proliferation and apoptosis in SaOs-2 cells. no no
20067614 Smoothened as a new therapeutic target for human osteosarcoma. yes no
20357441 Molecular mechanism of cell apoptosis by paclitaxel and pirarubicin in a human osteosarcoma cell line. no no
21458381 Cyclin E1 is amplified and overexpressed in osteosarcoma. yes yes
22682620 MicroRNA profiling with correlation to gene expression revealed the oncogenic miR-17-92 cluster to be up-regulated in osteosarcoma. no no
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