Results for CDK1

General Information

Gene ID 983
Gene Symbol CDK1
Gene Name cyclin-dependent kinase 1
Gene Type protein-coding
Cytoband 10q21.1
Ensembl ID ENSG00000170312
#miR regulators 9
Omim ID 116940
Gene ontology GO:0006260: DNA replication
GO:0000082: G1/S transition of mitotic cell cycle
GO:0000083: regulation of transcription involved in G1/S phase of mitotic cell cycle
GO:0000086: G2/M transition of mitotic cell cycle
GO:0000165: MAPK cascade
GO:0000186: activation of MAPKK activity
GO:0000187: activation of MAPK activity
GO:0000226: microtubule cytoskeleton organization
GO:0000278: mitotic cell cycle
GO:0002224: toll-like receptor signaling pathway
GO:0002755: MyD88-dependent toll-like receptor signaling pathway
GO:0002756: MyD88-independent toll-like receptor signaling pathway
GO:0006915: apoptotic process
GO:0006281: DNA repair
GO:0006461: protein complex assembly
GO:0007067: mitosis
GO:0007077: mitotic nuclear envelope disassembly
GO:0007095: mitotic G2 DNA damage checkpoint
GO:0007098: centrosome cycle
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007264: small GTPase mediated signal transduction
GO:0007265: Ras protein signal transduction
GO:0007344: pronuclear fusion
GO:0007411: axon guidance
GO:0007569: cell aging
GO:0043066: negative regulation of apoptotic process
GO:0008286: insulin receptor signaling pathway
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0042493: response to drug
GO:0009636: response to toxic substance
GO:0010628: positive regulation of gene expression
GO:0014038: regulation of Schwann cell differentiation
GO:0014070: response to organic cyclic compound
GO:0014075: response to amine stimulus
GO:0014823: response to activity
GO:0016477: cell migration
GO:0046686: response to cadmium ion
GO:0030261: chromosome condensation
GO:0031100: organ regeneration
GO:0031145: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0033160: positive regulation of protein import into nucleus, translocation
GO:0034134: toll-like receptor 2 signaling pathway
GO:0034138: toll-like receptor 3 signaling pathway
GO:0034142: toll-like receptor 4 signaling pathway
GO:0034146: toll-like receptor 5 signaling pathway
GO:0034162: toll-like receptor 9 signaling pathway
GO:0034166: toll-like receptor 10 signaling pathway
GO:0034501: protein localization to kinetochore
GO:0035666: TRIF-dependent toll-like receptor signaling pathway
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0038123: toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124: toll-like receptor TLR6:TLR2 signaling pathway
GO:0045087: innate immune response
GO:0046688: response to copper ion
GO:0045471: response to ethanol
GO:0045740: positive regulation of DNA replication
GO:0045931: positive regulation of mitotic cell cycle
GO:0045995: regulation of embryonic development
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0048678: response to axon injury
GO:0051301: cell division
GO:0051403: stress-activated MAPK cascade
GO:0051437: positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439: regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0055015: ventricular cardiac muscle cell development
GO:0060045: positive regulation of cardiac muscle cell proliferation
GO:0070301: cellular response to hydrogen peroxide
GO:0005739: mitochondrion
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005815: microtubule organizing center
GO:0005876: spindle microtubule
GO:0030496: midbody
GO:0005515: protein binding
GO:0004672: protein kinase activity
GO:0004693: cyclin-dependent protein serine/threonine kinase activity
GO:0005524: ATP binding
GO:0008353: RNA polymerase II carboxy-terminal domain kinase activity
GO:0030332: cyclin binding
GO:0030544: Hsp70 protein binding
GO:0035173: histone kinase activity
KEGG pathways 4110: Cell cycle
4114: Oocyte meiosis
4115: p53 signaling pathway
4540: Gap junction
4914: Progesterone-mediated oocyte maturation

PubMed abstracts associated with CDK1

PMID Title Tumor Value
8052269 Insulin-like growth factor-I induces cyclin-D1 expression in MG63 human osteosarcoma cells in vitro. no no
8550801 1 alpha, 25-dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol (Ro24-5531) modulation of insulin-like growth factor-binding protein-3 and induction of differentiation and growth arrest in a human osteosarcoma cell line. no no
16849574 E2F-1 overexpression in U2OS cells increases cyclin B1 levels and cdc2 kinase activity and sensitizes cells to antimitotic agents. no no
16982772 Combined depletion of cell cycle and transcriptional cyclin-dependent kinase activities induces apoptosis in cancer cells. no no
20044614 Curcumin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. no no
21331449 Gambogic acid inhibits the growth of osteosarcoma cells in vitro by inducing apoptosis and cell cycle arrest. no no
21490307 The cyclin-dependent kinase inhibitor SCH 727965 (dinacliclib) induces the apoptosis of osteosarcoma cells. no no
21720717 Induction of G?/M arrest and apoptosis by sulforaphane in human osteosarcoma U2-OS cells. no no
22231496 Daphnoretin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. no no
23470834 Melatonin inhibits the proliferation of human osteosarcoma cell line MG-63. no no
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