General Information
Gene ID | 983 |
---|---|
Gene Symbol | CDK1 |
Gene Name | cyclin-dependent kinase 1 |
Gene Type | protein-coding |
Cytoband | 10q21.1 |
Ensembl ID | ENSG00000170312 |
#miR regulators | 9 |
Omim ID | 116940 |
Gene ontology |
GO:0006260: DNA replication GO:0000082: G1/S transition of mitotic cell cycle GO:0000083: regulation of transcription involved in G1/S phase of mitotic cell cycle GO:0000086: G2/M transition of mitotic cell cycle GO:0000165: MAPK cascade GO:0000186: activation of MAPKK activity GO:0000187: activation of MAPK activity GO:0000226: microtubule cytoskeleton organization GO:0000278: mitotic cell cycle GO:0002224: toll-like receptor signaling pathway GO:0002755: MyD88-dependent toll-like receptor signaling pathway GO:0002756: MyD88-independent toll-like receptor signaling pathway GO:0006915: apoptotic process GO:0006281: DNA repair GO:0006461: protein complex assembly GO:0007067: mitosis GO:0007077: mitotic nuclear envelope disassembly GO:0007095: mitotic G2 DNA damage checkpoint GO:0007098: centrosome cycle GO:0007173: epidermal growth factor receptor signaling pathway GO:0007264: small GTPase mediated signal transduction GO:0007265: Ras protein signal transduction GO:0007344: pronuclear fusion GO:0007411: axon guidance GO:0007569: cell aging GO:0043066: negative regulation of apoptotic process GO:0008286: insulin receptor signaling pathway GO:0008543: fibroblast growth factor receptor signaling pathway GO:0042493: response to drug GO:0009636: response to toxic substance GO:0010628: positive regulation of gene expression GO:0014038: regulation of Schwann cell differentiation GO:0014070: response to organic cyclic compound GO:0014075: response to amine stimulus GO:0014823: response to activity GO:0016477: cell migration GO:0046686: response to cadmium ion GO:0030261: chromosome condensation GO:0031100: organ regeneration GO:0031145: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0033160: positive regulation of protein import into nucleus, translocation GO:0034134: toll-like receptor 2 signaling pathway GO:0034138: toll-like receptor 3 signaling pathway GO:0034142: toll-like receptor 4 signaling pathway GO:0034146: toll-like receptor 5 signaling pathway GO:0034162: toll-like receptor 9 signaling pathway GO:0034166: toll-like receptor 10 signaling pathway GO:0034501: protein localization to kinetochore GO:0035666: TRIF-dependent toll-like receptor signaling pathway GO:0038095: Fc-epsilon receptor signaling pathway GO:0038123: toll-like receptor TLR1:TLR2 signaling pathway GO:0038124: toll-like receptor TLR6:TLR2 signaling pathway GO:0045087: innate immune response GO:0046688: response to copper ion GO:0045471: response to ethanol GO:0045740: positive regulation of DNA replication GO:0045931: positive regulation of mitotic cell cycle GO:0045995: regulation of embryonic development GO:0048011: neurotrophin TRK receptor signaling pathway GO:0048678: response to axon injury GO:0051301: cell division GO:0051403: stress-activated MAPK cascade GO:0051437: positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051439: regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0055015: ventricular cardiac muscle cell development GO:0060045: positive regulation of cardiac muscle cell proliferation GO:0070301: cellular response to hydrogen peroxide GO:0005739: mitochondrion GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0005654: nucleoplasm GO:0005815: microtubule organizing center GO:0005876: spindle microtubule GO:0030496: midbody GO:0005515: protein binding GO:0004672: protein kinase activity GO:0004693: cyclin-dependent protein serine/threonine kinase activity GO:0005524: ATP binding GO:0008353: RNA polymerase II carboxy-terminal domain kinase activity GO:0030332: cyclin binding GO:0030544: Hsp70 protein binding GO:0035173: histone kinase activity |
KEGG pathways |
4110: Cell cycle 4114: Oocyte meiosis 4115: p53 signaling pathway 4540: Gap junction 4914: Progesterone-mediated oocyte maturation |
PMID | Title | Tumor | Value |
---|---|---|---|
8052269 | Insulin-like growth factor-I induces cyclin-D1 expression in MG63 human osteosarcoma cells in vitro. | no | no |
8550801 | 1 alpha, 25-dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol (Ro24-5531) modulation of insulin-like growth factor-binding protein-3 and induction of differentiation and growth arrest in a human osteosarcoma cell line. | no | no |
16849574 | E2F-1 overexpression in U2OS cells increases cyclin B1 levels and cdc2 kinase activity and sensitizes cells to antimitotic agents. | no | no |
16982772 | Combined depletion of cell cycle and transcriptional cyclin-dependent kinase activities induces apoptosis in cancer cells. | no | no |
20044614 | Curcumin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. | no | no |
21331449 | Gambogic acid inhibits the growth of osteosarcoma cells in vitro by inducing apoptosis and cell cycle arrest. | no | no |
21490307 | The cyclin-dependent kinase inhibitor SCH 727965 (dinacliclib) induces the apoptosis of osteosarcoma cells. | no | no |
21720717 | Induction of G₂/M arrest and apoptosis by sulforaphane in human osteosarcoma U2-OS cells. | no | no |
22231496 | Daphnoretin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. | no | no |
23470834 | Melatonin inhibits the proliferation of human osteosarcoma cell line MG-63. | no | no |
title | all | all |