Results for CXCR4

General Information

Gene ID 7852
Gene Symbol CXCR4
Gene Name chemokine (C-X-C motif) receptor 4
Gene Type protein-coding
Cytoband 2q21
Ensembl ID ENSG00000121966
#miR regulators 3
Omim ID 162643 193670
Gene ontology GO:0000187: activation of MAPK activity
GO:0001569: patterning of blood vessels
GO:0001666: response to hypoxia
GO:0001667: ameboidal cell migration
GO:0001764: neuron migration
GO:0002407: dendritic cell chemotaxis
GO:0009615: response to virus
GO:0006915: apoptotic process
GO:0006954: inflammatory response
GO:0007186: G-protein coupled receptor signaling pathway
GO:0007204: elevation of cytosolic calcium ion concentration
GO:0019722: calcium-mediated signaling
GO:0007281: germ cell development
GO:0007420: brain development
GO:0008045: motor neuron axon guidance
GO:0008354: germ cell migration
GO:0016032: viral process
GO:0019048: modulation by virus of host morphology or physiology
GO:0030260: entry into host cell
GO:0030334: regulation of cell migration
GO:0042098: T cell proliferation
GO:0042119: neutrophil activation
GO:0043217: myelin maintenance
GO:0048714: positive regulation of oligodendrocyte differentiation
GO:0050920: regulation of chemotaxis
GO:0061351: neural precursor cell proliferation
GO:0071345: cellular response to cytokine stimulus
GO:0005886: plasma membrane
GO:0016021: integral to membrane
GO:0005764: lysosome
GO:0005737: cytoplasm
GO:0005769: early endosome
GO:0005770: late endosome
GO:0009897: external side of plasma membrane
GO:0009986: cell surface
GO:0016023: cytoplasmic membrane-bounded vesicle
GO:0030426: growth cone
GO:0031252: cell leading edge
GO:0031410: cytoplasmic vesicle
GO:0005515: protein binding
GO:0001618: virus receptor activity
GO:0003779: actin binding
GO:0004930: G-protein coupled receptor activity
GO:0015026: coreceptor activity
GO:0016494: C-X-C chemokine receptor activity
GO:0019955: cytokine binding
GO:0031625: ubiquitin protein ligase binding
GO:0032027: myosin light chain binding
GO:0043130: ubiquitin binding
KEGG pathways 4060: Cytokine-cytokine receptor interaction
4062: Chemokine signaling pathway
4144: Endocytosis
4360: Axon guidance
4670: Leukocyte transendothelial migration
4672: Intestinal immune network for IgA production

PubMed abstracts associated with CXCR4

PMID Title Tumor Value
15701832 Involvement of chemokine receptor 4/stromal cell-derived factor 1 system during osteosarcoma tumor progression. no no
15746965 Chemokine receptor CXCR4-beta1 integrin axis mediates tumorigenesis of osteosarcoma HOS cells. no no
15814634 Messenger RNA expression levels of CXCR4 correlate with metastatic behavior and outcome in patients with osteosarcoma. yes yes
16528367 CXCR4 and VEGF expression in the primary site and the metastatic site of human osteosarcoma: analysis within a group of patients, all of whom developed lung metastasis. yes yes
18339860 Deletion of Yin Yang 1 protein in osteosarcoma cells on cell invasion and CXCR4/angiogenesis and metastasis. no no
19496172 Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways. no no
20349215 Relationships between levels of CXCR4 and VEGF and blood-borne metastasis and survival in patients with osteosarcoma. yes yes
20460510 CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance. no no
22173290 Strong expression of CXCL12 is associated with a favorable outcome in osteosarcoma. yes yes
23192273 IL-17A/IL-17RA interaction promoted metastasis of osteosarcoma cells. yes no
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